Sökning: "insulin receptor substrate-1"

Visar resultat 11 - 13 av 13 avhandlingar innehållade orden insulin receptor substrate-1.

1. 11. The regulatory role of microRNA in human adipocytes and their link to insulin resistance

   Författare :Yasmina Belarbi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : White adipose tissue (WAT) is a highly plastic organ which secretes a large number of peptide factors termed adipokines. Increased caloric intake increases WAT mass which results in marked alterations in the secretory pattern. This may be mediated via both transcriptional and post-transcriptional mechanisms. LÄS MER

3. 12. Role of Cell-cell Interactions and Palmitate on β-cells Function

   Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER

4. 13. Molecular Genetic Studies on Prostate and Penile Cancer

   Författare :Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

   Sammanfattning : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. LÄS MER