Sökning: "injury mechanism"
Visar resultat 41 - 45 av 215 avhandlingar innehållade orden injury mechanism.
41. The role and mechanism of ubiquitin system in innate immune regulation
Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER
42. Experimental spinal cord injury : development of protection and repair strategies in rats
Sammanfattning : Spinal cord injury typically results in neurological deficits that can not be reversed, often leaving patients bound to a wheelchair. Current treatment strategies are not very successful. Despite many promising experimental strategies, clinical translation has so far been very limited. LÄS MER
43. Is it possible to predict the outcome of an anterior cruciate ligament injury?
Sammanfattning : This thesis centers on a well-studied cohort of 100 patients, which received a treatment regimen of initial rehabilitation and activity modification to cope with Anterior Cruciate Ligament (ACL) injury. The data, collected prospectively and longitudinally, cover a span of 15 years after initial injury. LÄS MER
44. Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems
Sammanfattning : Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). Combat-related TBI inflicted by explosive blast (bTBI) is highly prevalent among military personnel. LÄS MER
45. Developing brain and systemic inflammation: a "Toll-like" link with consequences
Sammanfattning : The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. LÄS MER