Sökning: "inhibitory activity"

Visar resultat 1 - 5 av 436 avhandlingar innehållade orden inhibitory activity.

  1. 1. Nicotine sensitization and loss of inhibitory control. Role of serotonin

    Författare :Peter Olausson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nicotine; Amphetamine; Locomotor activity; Inhibitory control; Dopamine; Serotonin; Sensitization; Nucleus accumbens; Elevated plus-maze;

    Sammanfattning : Drug dependence is a devastating disorder present in all parts of the world. It is manifested by craving and a general loss of control over the drug intake and the life situation, ultimately leading to compulsive use of the addictive drug at the expense of normal behavioral patterns. LÄS MER

  2. 2. Production, Purification and Characterization of Antimicrobial Biomolecules from Potential Probiotic Lactic Acid Bacteria

    Författare :Sahar Deraz; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Lactobacillus; Bioteknik; Biotechnology; Livsmedelsteknik; Food and drink technology; bacteriocin purification.; inhibitory activity; Bacteriocin; antimicrobial protein;

    Sammanfattning : Development and optimization of the production of lactic acid bacteria (LAB) and their attendant 'natural' inhibitors as biopreservatives to control undesirable bacteria currently remains a primary focus of several laboratories involved in research concerning food safety and quality. Strategies utilized to study incorporation of biopreservatives into food include either direct use of LAB-strains or use of a biopreservative preparation in the form of previously fermented product or use of semipurified, purified, or chemically synthesized bacteriocins. LÄS MER

  3. 3. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    Författare :Tina Seifert; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Sammanfattning : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. LÄS MER

  4. 4. DNA Analysis of PCR-Inhibitory Forensic Samples

    Författare :Johannes Hedman; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; amylase; statistical modelling; principal components analysis; PCR inhibitors; PCR inhibition; forensic DNA analysis; DNA polymerase blend; DNA polymerase; crime scene samples;

    Sammanfattning : DNA evidence, linking perpetrators to crime scenes, is central to many legal proceedings. However, crime scene samples often contain extraneous substances that may interfere with the PCR-based forensic analysis, resulting in partial or negative DNA profiles. Extensive DNA purification may remove inhibitors, but involves the risk of DNA loss. LÄS MER

  5. 5. Studies on inhibitory modulation of urinary tract motility

    Författare :Na Guan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Overactive Bladder (OAB) is a symptom syndrome characterized by urgency and frequency, with or without urge incontinence. Research concerning the mechanisms underlying OAB and finding new inhibitory factor(s) is intensive. LÄS MER