Sökning: "inherited susceptibility"

Visar resultat 16 - 20 av 45 avhandlingar innehållade orden inherited susceptibility.

  1. 16. Genetic studies of autism and autistic-like traits

    Författare :Lina Jonsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASD; ALT; Genetics; Melatonin;

    Sammanfattning : Autism spectrum disorder (ASD) is characterized by impairment in social interaction, language impairment and repetitive behavior with varying degrees of severity. ASD represents the lower end on a continuously distributed measure of autistic-like traits (ALTs). LÄS MER

  3. 17. Human leukocyte antigens with special reference to association and linkage in multiple sclerosis

    Författare :Anna Fogdell-Hahn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HLA; MHC; multiple sclerosis; narcolepsy; lod score; linkage.;

    Sammanfattning : The polymorphism of HLA (human leukocyte antigen) is extensive. Allelic variation has previously been detected by cellular and serological methods. Today a variety of genomic typing techniques have been developed, which give higher resolution and a possibility to detect single nucleotide variations. LÄS MER

  4. 18. LIVING WITH PARASITES: AVIAN MALARIA, TELOMERE LENGTH AND LIFE HISTORY TRADE-OFFS

    Författare :Asghar Muhammad; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Avian malaria; Plasmodium; qPCR; parasitemia; life history; reproduction; survival; feather growth; MHC; telomere length; heritability; telomere loss; fitness; wild population; Acrocephalus arundinaceus; Delichon urbica;

    Sammanfattning : Haemosporidia is a well-studied group of parasites, which infect mammals, reptiles and birds and use blood sucking vectors for their transmission. By conducting natural population studies and experimental infections, We have been able to detect and quantify Haemosporidia from avian blood to investigate how these pathogens affect their avian hosts. LÄS MER

  5. 19. Gene expression profiling in animal models of alcoholism

    Författare :Christina Arlinde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alcoholism; gene expression; microarray; animal model; rat; brain;

    Sammanfattning : Genetic and environmental factors in alcoholism interact at the level of the transcriptome to encode the phenotypic traits of this complex clinical syndrome. Because of this, the prospect of simultaneous, genome wide, high-throughput analysis of gene expression in key brain areas potentially offers a novel strategy to identify new molecular treatment targets in this disease. LÄS MER

  7. 20. On the genetics of hereditary breast/ovarian cancer. BRCA1, BRCA2 and beyond

    Författare :Annika Bergman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; breast cancer; hereditary cancer; founder mutation; mutation analysis; linkage analysis; genome scan; BRCAX;

    Sammanfattning : Breast cancer is the most common malignancy in women. Most of the breast cancers are sporadic with no apparent inheritance factor but about 5-10% is believed to be caused by an inherited predisposition. Aims: This thesis aimed at defining the BRCA1/2 mutation spectrum of the west Swedish population and specifically to characterize the BRCA1c. LÄS MER