Sökning: "inherited predisposition"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden inherited predisposition.

  1. 1. Genetic Predisposition to Sporadic and Familial Multiple Myeloma

    Författare :Britt-Marie Halvarsson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; genetics; inherited predisposition; familial multiple myeloma; GWAS; polygenic risk score;

    Sammanfattning : Multiple Myeloma (MM) is the second most common hematological malignancy. It is defined by an uncontrolled growth of plasma cells, usually in the bone marrow. Clinically it is complicated by hypercalcemia, renal failure, anaemia, and bone pain. LÄS MER

  3. 2. Hereditary predisposition and prognostic prediction in cancer

    Författare :Karin Wallander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a genetic disease. The cancer cells evolve clonally through changes of their genome, gaining malignant characteristics. In hereditary cancer syndromes, a genetic aberration which puts the cells one step closer to being malignant is inherited and present throughout whole body. LÄS MER

  4. 3. Investigation of genetic factors involved in colorectal cancer predisposition

    Författare :Tatjana Djureinovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :colorectal cancer CRC ; hereditary colorectal cancer HCRC ; two-close relatives TCR ; linkage analysis; case-control;

    Sammanfattning : Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the western world. Several hereditary CRC predisposing syndromes have been described and their genetic component has been elucidated. Taken together, these syndromes account for at most 5% of all CRC cases. LÄS MER

  5. 4. Evaluation of genetic cancer predisposition and potential cancer genes

    Författare :Yaxuan Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer (hTP53rc) syndrome. LFS is a rare inherited cancer syndrome characterized by premenopausal breast cancer, soft tissue sarcoma, brain tumor, osteosarcoma, and adrenocortical carcinoma. LÄS MER

  7. 5. Identification and characterization of DNA sequence variants associated with multiple myeloma

    Författare :Mina Ali; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :Multiple myeloma; inherited susceptibility; genome-wide association study; ELL2; expression quantitative trait loci;

    Sammanfattning : Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is characterized by an uncontrolled growth of malignant plasma cells in the bone marrow, producing a monoclonal immunoglobulin (“M protein”) that can be detected in peripheral blood. LÄS MER