Sökning: "inheritance"
Visar resultat 21 - 25 av 243 avhandlingar innehållade ordet inheritance.
21. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
Sammanfattning : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. LÄS MER
22. Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans
Sammanfattning : The membrane system of a eukaryotic cell is a large and complex system handling the transport, exchange and degradation of many kinds of material. Recent research shows that double-stranded RNA (dsRNA) mediated gene silencing (RNA interference) is a membrane related process. LÄS MER
23. Stress response regulation and protein aggregate inheritance in Caulobacter crescentus
Sammanfattning : Many stress conditions a cell encounters threaten the continuation of basic biological processes ultimately endangering its survival. Heat shock and antibiotic exposure can lead to a sudden surge of protein un- and misfolding, while nutrient starvation directly causes a lack of energy and molecular building blocks. LÄS MER
24. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans
Sammanfattning : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. LÄS MER
25. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
Sammanfattning : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. LÄS MER