Sökning: "inhaler"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet inhaler.

  1. 1. Advancing portable, aqueous drug delivery to the human lung

    Författare :Torben Last; Göran Stemme; Niclas Roxhed; Claus-Michael Lehr; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Portable Inhaler; Biopharmaceuticals; Soft-mist inhaler; Transport vesicles; Microfluidic packaging; High-pressure microfluidics; aerosolization; cleanroom-free fabrication; drug delivery; micro-electromechanical systems MEMS ; Applied Medical Technology; Tillämpad medicinsk teknik;

    Sammanfattning : Lung disease profoundly impacts human health: many lung diseases are currently without cure and require continued treatment. Due to their ease of use and integration into the daily routine, portable inhalers are the preferred treatment option for patients. LÄS MER

  3. 2. Inhaled pharmacological treatment and critical inhaler technique errors in patients with chronic obstructive pulmonary disease

    Författare :Johanna Sulku; Elisabet I. Nielsen; Alf Tunsäter; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic obstructive pulmonary disease; COPD; critical inhaler technique error; pharmacological treatment; ICS; inhaled corticosteroid; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterised by persistent respiratory symptoms and a high risk of exacerbations. Preventive and maintenance pharmacological treatment is primarily administered through handheld inhalers, which are available in several different device-drug combinations. LÄS MER

  4. 3. Deposition and absorption of inhaled drugs

    Författare :Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

    Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER

  5. 4. Powder mechanics and dispersion properties of adhesive mixtures for dry powder inhalers : Conceptualized as a blend state model

    Författare :Jonas Rudén; Göran Alderborn; Göran Frenning; Tobias Bramer; Kyrre Thalberg; Regina Scherliess; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inhalation; Dry Powder Inhaler; adhesive mixture; aerosols; powder mechanics; dispersibility; aerosolization; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Inhaled medicines is a therapy that dates back several thousands of years. Nowadays, using various types of inhaler devices to deliver active pharmaceutical ingredients (APIs) to treat respiratory diseases has become common practice. LÄS MER

  7. 5. Understanding Adhesive Mixtures for Inhalation : Particle Dynamics Modelling and Segregation Experiments

    Författare :Sohan Sarangi; Göran Frenning; Göran Alderborn; Kyrre Thalberg; Johannes Khinast; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inhalation; adhesive mixtures; dry powder inhaler; discrete element method; segregation; stability; modeling; Galenisk farmaci; Pharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pulmonary route has been used as a source of drug delivery to lungs for centuries. Drugformulation decides the type of inhaler devices such as pressurized metered-dose inhalers(pMDIs), nebulizers and dry powder inhalers (DPIs). LÄS MER