Sökning: "inflammasome"

Visar resultat 16 - 20 av 50 avhandlingar innehållade ordet inflammasome.

  1. 16. Dental acrylates and methacrylates - Interactions with the immune system

    Författare :Sara Alizadehgharib; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acrylates; Methacrylates; Antibodies; NLRP3 inflammasome; Cytokines; Mice; Hydrogen sulfide;

    Sammanfattning : Professionals working in dentistry have reported adverse effects, such as allergic contact dermatitis due to exposure to different methacrylates/acrylates. Leakage of such monomers from dental fillings due to incomplete curing is also common. LÄS MER

  3. 17. Cobalt in the hard metal production industry : exposure via inhalation and skin and the inflammatory response in human keratinocytes

    Författare :Maria Klasson; Eva Särndahl; Håkan Westberg; Magnus Lindberg; Alexander Persson; Kristina Jakobsson; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cobalt; cobalt chloride; skin; HaCaT; in vitro; cell viability; pro-inflammatory cytokines; NLRP3 inflammasome;

    Sammanfattning : Cobalt is a strong sensitizer and can cause contact allergy upon both direct contact or from airborne exposure on the skin. In the skin, keratinocytes are the first cells to come in contact with the metal and will react and respond to the danger by triggering an alarm system resulting in an inflammatory response in the skin. LÄS MER

  4. 18. Importance of bacterial hydrogen sulfide in the pathogenesis of periodontal diseases

    Författare :Amina Basic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hydrogen sulfide; Periodontitis; Gingivitis; IL-1β; IL-18; NLRP3 inflammasome; Oral microbiota; Fusobacterium spp.; Bismuth test; L-cysteine;

    Sammanfattning : Hydrogen sulfide (H2S) is one of many end-products of the proteolytic activities in the subgingival microbiota in patients with periodontal diseases, such as gingivitis and periodontitis. Although H2S is generally regarded as toxic, the mechanisms that underlie its production and its effects on human cells and tissues are poorly understood. LÄS MER

  5. 19. Determining the role of guanylate-binding proteins for host defense against Francisella tularensis

    Författare :Nasibeh Mohammadi; Anders Sjöstedt; Wolfgang P. Schröder; Anetta S. Härtlova; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Guanylate-binding proteins; bone marrow-derived macrophages; IFN-γ activation; cytokine patterns; inflammasome pathways; co-infection; mouse co-culture model; Biochemistry; biokemi; immunologi; Immunology; mikrobiologi; Microbiology; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Francisella tularensis is a highly virulent, intracellular bacterium and the causative agent of the human disease tularemia. This is a zoonotic, often vector-borne disease. Due to its intracellular nature, F. LÄS MER

  7. 20. Silica particle-induced NLRP3 inflammasome activation and DNA damage in respiratory epithelium

    Författare :Rongrong Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Respirable crystalline silica particles (CSi) can persist and induce inflammation and DNA damage in human lungs. Previous studies have used complex model systems to characterize CSi-induced DNA damage, involving co-cultures of epithelial cells and macrophages and long-term exposures, necessitating alternative models. LÄS MER