Sökning: "infektionsmedicin"

Visar resultat 1 - 5 av 280 avhandlingar innehållade ordet infektionsmedicin.

  1. 1. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER

  3. 2. Molecular characterization of the hepatitis C virus core protein

    Författare :Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Sammanfattning : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. LÄS MER

  4. 3. Clinical, epidemiological and immunological aspects of Lyme borreliosis with special focus on the role of the complement system

    Författare :Anna J Henningsson; Jan Ernerudh; Pia Forsberg; Kristina Nilsson Ekdahl; Bo-Eric Malmvall; Lars Hagberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lyme borreliosis; neuroborreliosis; clinical; epidemiology; inflammation; complement; cytokine; chemokine;

    Sammanfattning : Lyme borreliosis (LB) is the most common vector-borne disease in the Northern Hemisphere. The infection is caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and it is transmitted to humans by ticks. LÄS MER

  5. 4. Study of Resistance in Hepatitis C Virus Prior to Treatment with Direct Acting Antivirals

    Författare :Midori Kjellin; Johan Lennerstrand; Nina Weis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C; HCV; DAA; RAS; resistance-associated substitution; baseline resistance; NS5A; NS3; SVR; Medical Virology; Medicinsk virologi; Mikrobiologi; Microbiology; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : The rapid advancement of Hepatitis C (HCV) treatment presents a great challenge to clinicians in optimising therapy for their patients. Genotype (GT), efficacy, side-effects, drug combinations and treatment durations must be tailored to individual patients, considering comorbidities, degree of fibrosis, adherence and antiviral resistance. LÄS MER

  7. 5. Neoehrlichia mikurensis in Sweden : An emerging tick-borne human pathogen

    Författare :Lisa Labbé Sandelin; Björn Olsen; Jonas Waldenström; Per-Eric Lindgren; Ivar Tjernberg; Lars Hagberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neoehrlichia; Tick-borne Infections; Transfusion-transmitted infections; Bacterial Zoonotic infections; Blood Donors; Immunosuppression; Infectious Diseases; Emerging; Blood Safety; Bird Migration; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Neoehrlichia mikurensis is an emerging tick-borne human pathogen, causing neoehrlichiosis in immunosuppressed and immunocompetent individuals. It targets the vascular endothelium, leading to thromboembolic and vascular events, but can also pass without symptoms. LÄS MER