Sökning: "infection reactivation"
Visar resultat 16 - 20 av 35 avhandlingar innehållade orden infection reactivation.
16. Immune evasion and dissemination of Toxoplasma gondii
Sammanfattning : Toxoplasma gondii is an obligate intracellular protozoan parasite which propagates in a complex life cycle where infection of Felidae family-members (Cats) results in sexual recombination whereas all other warm-blooded animals are intermediate hosts. Approximately one third of the human population is estimated to be chronically infected by this parasite. LÄS MER
17. Studies on the role of SOCS3 and STAT3 in development and function of the immune system
Sammanfattning : The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the innate host defenses and establish the infection in the host. LÄS MER
18. Innate and adaptive immune responses in viral and chronic inflammatory diseases
Sammanfattning : In this thesis I address some important questions regarding innate and adaptiveimmune responses in different human diseases. We analysed two distinctconditions: chronic autoimmune inflammation, specifically SLE, and chronic viralinfection, represented by herpes simplex virus (HSV). LÄS MER
19. Malaria, B lymphocytes and Epstein-Barr virus : emerging concepts on Burkitt's lymphoma pathogenesis
Sammanfattning : Plasmodium falciparum and Epstein-Barr virus (EBV) infections are recognized co-factors in the genesis of endemic Burkitt's Lymphoma (eBL), the most common paediatric cancer in equatorial Africa. This thesis work examines and discusses interactions between Pfalciparum and EBV that could promote the emergence of eBL. LÄS MER
20. Dissemination of Toxoplasma gondii to the central nervous system : with special reference to in vivo bioluminescence imaging
Sammanfattning : Toxoplasma gondii causes an asymtomatic chronic infection in immune competent individuals that can be life-threatening in individuals that become immuno-compromised or to the developing fetus. This thesis aimed to (1) establish a novel murine model to study acute and reactivated toxoplasmosis in real-time using in vivo bioluminescence imaging (BLI), (2) investigate the migratory pathways utilized by Toxoplasma for systemic dissemination, especially to the central nervous system (CNS) and (3) address the role of resident brain glia cells in the setting of recrudescent infection in mice. LÄS MER