Sökning: "indolo[3"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet indolo[3.

  1. 1. Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands

    Författare :Niklas Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Indole; bisindoles; carbazole; indolocarbazole; indolo[3; 2-b]carbazole; ICZ; FICZ; alkaloid; metabolite; tropolone; caulersin; aryl hydrocarbon receptor; Ali receptor; X-ray crystallography; Lewis acid; acylation; Vilsmeier reaction.;

    Sammanfattning : This thesis deals with the synthesis and reactions of indoles, bisindoles, indolocarbazoles and their derivatives. New methods for ring formation of planar, heterocyclic quinones, with the indolo[3,2b]carbazole or indolo[2,3-b]carbazole structures are described. LÄS MER

  3. 2. Bisindoles : synthesis and reactions

    Författare :Eva Koch; KTH; []
    Nyckelord :;

    Sammanfattning : In this thesis, synthesis of various bisindoles have beendeveloped.2,3-Bis-(3-indolyl) succinic acid derivatives wereobtained via iodine promoted coupling of the trianion ofindole-3-acetic acid (IAA) or from the dianion of themethylester of IAA. These compounds were converted to2,3-bis(3-indolyl) maleimides (arcyriarubin analogues) by DDQoxidation. LÄS MER

  4. 3. Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety

    Författare :Robert Engqvist; jan Bergman; Victor Snieckus; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alkaloid; drug development; heterocycles; indole; metabolite; synthesis; X-ray crystallography;

    Sammanfattning : This thesis deals with the development of new synthetic methods leading to fused tri- and tetracyclic heterocycles, many of which have interesting biological activity such as antiviral and DNA intercalating properties. The reactions between isatins and 2-aminobenzylamine in acetic acid can give, depending on the conditions, either complex spirooxindoles or indolo[3,2-c]quinolin-6-ones. LÄS MER

  5. 4. Synthesis of indolocarbazoles, bisindoles and related sulfur containing systems

    Författare :Tomasz Janosik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alkaloids; bisindoles; dithiins; indoles; indolocarbazoles; metallation; pentathiepins; polysulfides; tetrathiocins; thionation; X-ray crystallography.;

    Sammanfattning : This thesis is focussed mainly on the synthesis and reactions of various indolocarbazoles, bisindoles and related sulfur containing systems, all possessing structural features present in many biologically active, natural or synthetic compounds. In the first part, synthetic routes towards the planar, pentacyclic ring systems of indolo[2,3-c]earbazole and indolo[3,2-a]carbazole are described. LÄS MER

  7. 5. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

    Författare :Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

    Sammanfattning : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. LÄS MER