Sökning: "increased sensitivity"

Visar resultat 1 - 5 av 1205 avhandlingar innehållade orden increased sensitivity.

  1. 1. Measurement of sensitivity to DNA damaging agents

    Författare :Sherin T Mathew; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Sammanfattning : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. LÄS MER

  2. 2. Body Composition in Adolescents with Type 1 Diabetes : Aspects of Glycaemic Control and Insulin Sensitivity

    Författare :Stefan Särnblad; Jan Åman; Torsten Tuvemo; Jan Bolinder; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; Type 1 diabetes mellitus; Adolescent; Body composition; Physical activity; Energy intake; Metformin; Insulin sensitivity; Pediatrik; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : Excessive weight gain has frequently been reported in adolescents with type 1 diabetes, especially in girls. In general, puberty is associated with reduced insulin sensitivity that is further diminished by overweight. The causes and consequences of excessive weight gain in adolescents with type 1 diabetes are not fully understood. LÄS MER

  3. 3. Conditions associated with increased growth hormone and prolactin sensitivity

    Författare :Amira Said Mohammed Alkharusi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Growth Hormone (GH) and Prolactin (PRL) are critical regulators of body growth and metabolism. Secretion and actions of GH and PRL are regulated at several levels and by different factors. The biological actions of these hormones are initiated by their binding to the respective membrane bound receptors of GH and PRL (GHR and PRLR). LÄS MER

  4. 4. The growth hormone receptor and growth hormone sensitivity in man

    Författare :Ruth Wickelgren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :GH sensitivity; GH receptor; quantitative RT-PCR; IGF-I; skeletal muscle; adipose tissue; tissue-specific; promoter; 5´-untranslated region; psoriasis; epidermis;

    Sammanfattning : It is well established that the response to endogenous and exogenous growth hormone (GH) varies between individuals. For example, conditions with increased catabolic rate, such as trauma, sepsis and surgery, are believed to be associated with acquired GH insensitivity. LÄS MER

  5. 5. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides

    Författare :Matilda Lampinen Salomonsson; Mikael Hedeland; Ulf Bondesson; Calle Nilsson; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; Derivatization; mass spectrometry; glucuronide; drug metabolism; increased sensitivity; structural investigation; 2-chloro-1-methylpyridinium iodide CMPI ; 1-ethyl-3- 3-dimethylaminopropyl -carbodiimide EDC ; 2-picolylamine PA ; 1; 2-dimethylimidazole-4-sulfonyl chloride DMISC ; Farmaceutisk kemi;

    Sammanfattning : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. LÄS MER