Sökning: "in-vitro testing"

Visar resultat 21 - 25 av 165 avhandlingar innehållade orden in-vitro testing.

  1. 21. Chemosensitivity in Breast Cancer

    Författare :Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
    Nyckelord :Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

    Sammanfattning : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. LÄS MER

  3. 22. Premixed Acidic Calcium Phosphate Cements

    Författare :Jonas Åberg; Håkan Engqvist; Helena Brisby; Peter Thomsen; Marc Bohner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; monetite; brushite; bone void filler; injecatilbity; in vivo; in vitro;

    Sammanfattning : Calcium phosphate cements are used in medicine to fill bone defects or give support to screws and plates in fracture fixation. The cements are formed via mixing a powder with water and the mixture harden through a dissolution-precipitation reaction. LÄS MER

  4. 23. Effects of gold- and silver nanoparticles on the retina

    Författare :Patrik Maximilian Bauer; Funktionell zoologi; []
    Nyckelord :Microglia; Retina; In vitro; Nanoparticles;

    Sammanfattning : Over the past decade, a massive increase in the use of nanomaterials and nanoparticles (NPs) in both commercial and medical applications has occurred. Medical applications include advanced drug delivery vehicles, imaging and hyper thermic therapies. LÄS MER

  5. 24. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

    Författare :Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

    Sammanfattning : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. LÄS MER

  7. 25. On the structure and mechanical properties of in vitro salivary pellicles

    Författare :Hannah Boyd; Javier Sotres; Thomas Arnebrant; Rob Barker; Mark Rutland; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Salivary pellicles display exceptional hydration and lubrication performance. At present, there are still gaps in the understanding of how this is achieved. LÄS MER