Sökning: "in vivo test"

Visar resultat 21 - 25 av 251 avhandlingar innehållade orden in vivo test.

  1. 21. Metal ions in life : towards accurate computer-aided studies ofprotein-ion interactions

    Författare :Emma Ahlstrand; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

    Sammanfattning : The importance of ions in life sciences can not be overstated. The interaction betweenmetal ions and proteins is vital because it is involved in a variety of biological processes.The ions contribute to stability and function of proteins. Moreover, they are relevant indisease progression. LÄS MER

  3. 22. Amyloid-β and lysozyme proteotoxicity in Drosophila : Beneficial effects of lysozyme and serum amyloid P component in models of Alzheimer’s disease and lysozyme amyloidosis

    Författare :Liza Bergkvist; Ann-Christin Brorsson; Katarina Kågedal; Jan Johansson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In the work presented this thesis, two different conditions that are classified as protein misfolding diseases: Alzheimer's disease and lysozyme amyloidosis and proteins that could have a beneficial effect in these diseases, have been studied using Drosophila melanogaster, commonly known as the fruit fly. The fruit fly has been used for over 100 years to study and better understand fundamental biological processes. LÄS MER

  4. 23. On growth factors and titanium implant integration in bone

    Författare :Victoria Franke Stenport; Göteborgs universitet; []
    Nyckelord :growth factors; signal peptides; titanium implants; osseointegration; in vivo studies;

    Sammanfattning : PurposeThe purpose of the present thesis was to investigate the bone tissue response around titanium implants with one growth factor stimulating hormone and a few different growth factor substances.Material and methodsIn four studies (study I to IV) a rabbit model were used and the growth factors i.e. LÄS MER

  5. 24. Microvascular inflammatory response in the skin

    Författare :Vladimir Evilevitch; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; medicinsk instrumentering; Physiology; Fysiologi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; sodium nitroprusside; terbutaline; anandamide; TRPV1; skin prick test; vanilloid receptor; skin microcirculation; laser Doppler imaging; Plasma exudation; vasodilatation;

    Sammanfattning : This thesis examines the microvascular inflammatory response in the skin. The microvascular response includes vasodilatation and plasma exudation. In the first three studies, the combined response was measured in guinea pig skin with a technique based on detection of radiolabelled protein. LÄS MER

  7. 25. Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide

    Författare :Johanna S Ungerstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sepsis; endotoxin; tissue factor; cytokines; nicotinamide; coagulation; inflammation;

    Sammanfattning : In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes of morbidity and mortality in the intensive care. LÄS MER