Sökning: "in vivo studies"

Visar resultat 1 - 5 av 1959 avhandlingar innehållade orden in vivo studies.

  1. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Författare :Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. LÄS MER

  3. 2. Growth regulation in sarcomas : studies in vivo and in cell culture

    Författare :Avni Abdiu; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Sarcomas are malignant tumors of mesenchymal origin, and can arise in soft-tissue and in bones. It has been suggested that the abnormal growth regulation in sarcoma cells may be due to an autocrine mechanism, in which the cells are stimulated by an endogenous production of growth factors. LÄS MER

  4. 3. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro

    Författare :Sara Stridh; Peter Hansell; Mats Rundgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

    Sammanfattning : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. LÄS MER

  5. 4. NO Effect on Inflammatory Reaction in Extracorporeal Circulation : Ex vivo Studies

    Författare :Mika Lahtinen; Jan Borowiec; Per Venge; Vibeke Videm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Cardiac surgery; extracorporeal circulation; inflammatory reaction; NO; degranulation; neutrophil; eosinophil; basophil; complement; contact system; coagulation; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Clinical Chemistry; klinisk kemi;

    Sammanfattning : Nitric oxide (NO) is expressed in inflammatory tissues. However, NO effects are controversial in inflammation; NO is described as acting in a dose dependent manner and possess both pro-inflammatory and anti-inflammatory properties. LÄS MER

  7. 5. Studies on glial fibrillary acidic protein (GFAP) in human glioma cells : in vitro and in vivo

    Författare :Erik Bongcam-Rudloff; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER