Sökning: "in vivo reprogramming"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden in vivo reprogramming.

1. 1. Generation of induced neurons via direct conversion in vivo and in vitro

   Författare :Olof Torper; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular reprogramming; cell replacement therapies; induced dopaminergic neurons; in vivo reprogramming; Lentiviral vectors; AAV vectors;

   Sammanfattning : Cellular reprogramming is when one cell is changed into another. This involves structural modifications on the DNA of a cell resulting in a transcriptional change. This occurs naturally during development when early pluripotent cells gradually differentiate into more specialized cells that finally result in a complete organism. LÄS MER

3. 2. Cell reprogramming as a way to produce new functional neurons

   Författare :Maria Pereira; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :Cell reprogramming; brain repair; cell therapy; induced neurons; in vitro reprogramming; in vivo reprogramming; Parkinson s disease;

   Sammanfattning : .... LÄS MER

4. 3. Functional and Transcriptional Studies of Human Dopaminergic Neurons

   Författare :Marcella Birtele; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopaminergic Neurons; Cell reprogramming; Cell therapy; Induced neurons; In vitro reprogramming; In vivo reprogramming;

   Sammanfattning : Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). LÄS MER

5. 4. Generation of cortical neurons through reprogramming technology

   Författare :Giedre Miskinyte; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cortex; Reprogramming; human ES cells; transcription factor programming; cortical projection neurons; Human adult cortical slices;

   Sammanfattning : The human cortex is affected by several debilitating acute and chronic neurodegenerative disorders such as stroke, traumatic brain injury, amyotrophic lateral sclerosis and Alzheimer’s disease, which target specific types of cortical neurons. Emerging evidence indicates that stem cells and reprogrammed cells can be used to generate human cortical neurons both for cell replacement by transplantation, and for disease modeling and drug screening. LÄS MER

7. 5. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells

   Författare :Alexandra Gabriela Barros Ferreira; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell Reprogramming; Cancer cells; Tumor Antigen-presenting Cells; immunotherapy;

   Sammanfattning : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. LÄS MER