Sökning: "in vivo probing"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden in vivo probing.

  1. 6. Deciphering the role of 27-hydroxycholesterol in neurodegeneration

    Författare :Muhammad Al Mustafa Ismail; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cholesterol is constantly attributed to neurodegenerative diseases including Alzheimer’s disease (AD). This is due to the association of high blood cholesterol and the consequences of cholesterol metabolism in these conditions. LÄS MER

  3. 7. Probing brain microstructure with multidimensional diffusion MRI: Encoding, interpretation, and the role of exchange

    Författare :Björn Lampinen; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MRI; Diffusion; Human; Brain; Microstructure; Fysicumarkivet A:2021:Lampinen;

    Sammanfattning : Diffusion MRI (dMRI) is a non-invasive probe of human brain microstructure. It is a long-standing promise to use dMRI for ‘in vivo histology’ and estimate tissue quantities. However, this faces several challenges. First, the microstructure models used for dMRI data are based on assumptions that may cause erroneous interpretations. LÄS MER

  4. 8. Bacterial DNA repair and molecular search

    Författare :Arvid H. Gynnå; Johan Elf; Stephen Kowalczykowski; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA repair; DNA damage; homologous recombination; homologous repair; recombination; RecA; I-SceI; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Surveillance and repair of DNA damage is necessary in all kinds of life. Different types of DNA damage require different repair mechanisms, but these mechanisms are often similar in all domains of life. The most serious type of damage, double stranded DNA breaks, are for example repaired in conceptually similar ways in both bacteria and eukaryotes. LÄS MER

  5. 9. Galiellalactone Synthetic Studies

    Författare :Zilma Escobar; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; natural product; galiellalactone; prostate cancer; STAT3.;

    Sammanfattning : In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). LÄS MER

  7. 10. Methods for 2D and 3D Quantitative Microscopy of Biological Samples

    Författare :Amin Allalou; Carolina Wählby; Ida-Maria Sintorn; Ewert Bengtsson; Jens Rittscher; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Image analysis; cytmetry; model organism; zebrafish; screening; Computerized Image Processing; Datoriserad bildbehandling;

    Sammanfattning : New microscopy techniques are continuously developed, resulting in more rapid acquisition of large amounts of data. Manual analysis of such data is extremely time-consuming and many features are difficult to quantify without the aid of a computer. LÄS MER