Sökning: "in vivo dosimetry"

Visar resultat 21 - 25 av 35 avhandlingar innehållade orden in vivo dosimetry.

1. 21. Hemoglobin dosimetry and comparative toxicity of acrylamide and its metabolic glycidamide

   Författare :Emma Bergmark; Stockholms universitet; []
   Nyckelord :;

   Sammanfattning : Hemoglobin is a useful in vivo dosimeter for electrophilic compounds that react with nucleophilic sites in macromolecules and form covalently bound adducts. With the purpose of increasing the sensitivity of analysis of haemoglobin adducts, a method was developed for enriching adducted globin chains based on ion-exchange chromatography. LÄS MER

3. 22. Dosimetry Studies of Different Radiotherapy Applications using Monte Carlo Radiation Transport Calculations

   Författare :Shirin Abbasinejad Enger; Hans Lundqvist; Anders Ahnesjö; Irena Gudowska; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; External Beam Radiotherapy; Gadolinium Neutron Capture Therapy; Gadolinium Neutron Capture Brachytherapy; Targeted Radionuclide therapy; Detector Response Modelling; Monte Carlo Simulation.; Radiological physics; Radiofysik;

   Sammanfattning : Developing radiation delivery systems for optimisation of absorbed dose to the target without normal tissue toxicity requires advanced calculations for transport of radiation. In this thesis absorbed dose and fluence in different radiotherapy applications were calculated by using Monte Carlo (MC) simulations. LÄS MER

4. 23. Exploring nanosystems for biomedical applications focusing on photodynamic therapy and drug delivery

   Författare :Vladimir Kirejev; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Photodynamic therapy; PDT enhancement; Nitric oxide; NO-based PDT; Targeted drug delivery; Galectin-3; mTHPP; Cyclodextrin; CD-mTHPP conjugate; PpIX AuNP combination; Two-photon microscopy; FLIM; Cell phototoxicity; Ex vivo skin;

   Sammanfattning : The increasing incidences of cancer and related deaths call for the development of new and improved treatment modalities. Photodynamic therapy (PDT) today is an alternative to conventional treatments, but has limitations. This thesis explores different nanosystems with aim to improve PDT focusing on spectroscopic and ex vivo studies. LÄS MER

5. 24. Methods, Instrumentation and Mechanisms for Optical Characterization of Tissue and Treatment of Malignant Tumours

   Författare :Sara Pålsson; Atomfysik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; temperature; perfusion; PDT; photodynamic therapy; mechanisms; tissue characterization; instrumentation; optical biopsy; fluorescence spectroscopy; spectroscopy techniques; Raman spectroscopy; interstitial photodynamic therapy; photodynamic threshold dose; Atomic and molecular physics; Atom- och molekylärfysik;

   Sammanfattning : In this thesis, different optical methods utilising visible light for characterization of tissue have been developed and evaluated. The feasibility of many of these methods has been demonstrated in the laboratory or in animal experiments. LÄS MER

7. 25. On the Use of 76Br-labelled Monoclonal Antibodies for PET : Preclinical Evaluation of Halogenated Antibodies for Diagnosis and Treatment of Cancer

   Författare :Johanna Höglund; Katrine Riklund-Åhlström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; bromine-76; positron emission tomography; monoclonal antibodies; cancer; direct and indirect radiohalogenation; Onkologi; Oncology; Onkologi; radiologi; Radiology;

   Sammanfattning : Radioactive substances are used in vivo to localize and characterize malignant tumours, generally by scintigraphic methods. In this context positron emission tomography (PET) in combination with radiolabelled monoclonal antibodies (mAbs) may provide a sensitive and specific method for detection of cancer. LÄS MER