Sökning: "in vivo dosimetry"

Visar resultat 11 - 15 av 35 avhandlingar innehållade orden in vivo dosimetry.

  1. 11. In vivo dosimetry of some alkylating agents as a basis for risk estimation

    Författare :Dan Segerbäck; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The present study concerns in vivo dosimetry of ultimate electrophilic reagents as a step in risk estimation of mutagenic and carcinogenic chemicals. The level of reaction products with nucleophilic groups in macromolecules could be used for dose determination. LÄS MER

  3. 12. Astatine-211 radioimmunotherapy of ovarian cancer. Therapeutic efficacy, myelotoxicity, andradiation dosimetry in an animal model

    Författare :Jörgen Elgqvist; Göteborgs universitet; []
    Nyckelord :astatine; alpha-particles; monoclonal antibodies; radioimmunotherapy; ; ovarian cancer; myelotoxicity; therapeutic efficacy; radiation dosimetry; fractionation;

    Sammanfattning : Alpha-particle emitting radionuclides have recently obtained an increased attention whenconsidering new strategies for treating disseminated cancer. Astatine (211At), that emits alphaparticleswith a mean path length of 62 μm, a mean linear energy transfer (LET) of 111keV/Mum, and a half-life of 7. LÄS MER

  4. 13. Tools for the Advancement of Radiopharmaceutical Therapy

    Författare :Emma Mellhammar; Forskningsgruppen för Systemisk strålterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiopharmaceutical therapy; Nuclear medicine; Monte Carlo simulation; Intratherapeutic preclinical PET; Alpha particles; Beta Particles; radionuclides; Radiobiology; γ-H2AX; Dosimetry;

    Sammanfattning : Radiopharmaceutical therapy is used to treat cancers and other diseases with radiolabeled pharmaceuticals. The treatment targets specific cells, and the emitted ionizing radiation cause cytotoxic damage. Dosimetry is performed to estimate the absorbed dose from the energy deposited in the body. LÄS MER

  5. 14. Radiobiological studies with low energy ionizing radiation - dosimetric aspects

    Författare :Gustav Grafström; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; low energy; Radiobiology; dosimetry; cell model; Radiofarmaceutisk teknik; Radiopharmaceutical technology; radiobiologi; Nukleärmedicin; radiobiology; Nuclear medicine; animal model;

    Sammanfattning : Background: During the last 20 years both in vitro and in vivo models have been developed for studies of the cell killing characteristics of low energy electrons, e.g. Auger electrons. This thesis deals with radiobiological effects of radiation from indium isotopes in V79 cells in vitro (Paper I-III) and the rat testis in vivo (Paper IVV). LÄS MER

  7. 15. [68Ga]Exendin-4: Bench-to-Bedside : PET molecular imaging of the GLP-1 receptor for diabetes and cancer

    Författare :Ram kumar Selvaraju; Olof Eriksson; Olle Korsgren; Lars Johansson; Martin Gotthardt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; [68Ga]Exendin-4; beta cell imaging; insulinoma; dosimetry;

    Sammanfattning : Diabetes epidemic is underway. Beta cell dysfunction (BCF) and loss of beta cell mass (BCM) are known to be key events in its progression. Currently, there are no reliable techniques to estimate or follow the loss of BCM, in vivo. LÄS MER