Sökning: "in situ gel"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden in situ gel.

  1. 1. Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

    Författare :Helene Hägerström; Katarina Edsman; Arne Brodin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gel; rheology; mucoadhesion; mucosal drug delivery; in situ gel; gellan gum; Carbopol; tensile strength; nasal mucosa; intranasal administration; dielectric spectroscopy; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. LÄS MER

  3. 2. Further characterisation and applications of the diffusive gradients in thin films technique : In situ measurements of anions and cations in environmental waters

    Författare :Helene Österlund; Luleå tekniska universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Applied Geology; Tillämpad geologi;

    Sammanfattning : As both the toxicity and the mobility of trace elements are related to chemical forms present, robust methods for element speciation analysis are of great interest. During the last 15 years, hundreds of scientific articles have been published on the development and applications of the diffusive gradients in thin films (DGT) passive sampling technique. LÄS MER

  4. 3. Nano-particulate Silica Hydrogels Imaged in 2D and 3D using TEM: Effects of local pore structure on mass transport and applications in aggregation dynamics

    Författare :Charlotte Hamngren Blomqvist; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; silica gel; colloidal silica gel; interconnectivity; nanoporous; electron tomography; silica nanoparticle gel; mass transport; nanostructure; accessible volume fraction; 3D structure;

    Sammanfattning : Porous materials are frequently used in everyday applications including food science, pharmaceuticals, fuel cell membranes, batteries and solar cells. A key aspect in these porous materials is how their micro- and nano-structure affect the internal transport of for example water, particles or charges. The transport is a three-dimensional process. LÄS MER

  5. 4. Application of Padlock Probe Based Nucleic Acid Analysis In Situ

    Författare :Sara Henriksson; Mats Nilsson; Ulf Landegren; Harvest Gu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Padlock probe; rolling circle amplification; single cell gel electrophoresis assay; comet assay; Crimean Congo hemorrhagic fever virus; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The great variation displayed by nucleic acid molecules in human cells, and the continuous discovery of their impact on life, consequently require continuous refinements of molecular analysis techniques. Padlock probes and rolling circle amplification offer single nucleotide discrimination in situ, a high signal-to-noise ratio and localized detection within cells and tissues. LÄS MER

  7. 5. Controlled release gel formulations and preclinical screening of drug candidates

    Författare :Tofeeq Ur-Rehman; Gerhard Gröbner; Mikael Elofsson; Åsa Gylfe; Martin Malmsten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; poloxamer; drug delivery; micellization; DMSO; calorimetry; NMR. in situ gelation; chitosan; preclinical pharmacokinetics; type III secretion inhibitors; Physical chemistry; Fysikalisk kemi; Pharmaceutics; galenisk farmaci;

    Sammanfattning : Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. LÄS MER