Sökning: "in silico modeling"

Visar resultat 6 - 10 av 34 avhandlingar innehållade orden in silico modeling.

1. 6. In silico prediction of CIS-regulatory elements

   Författare :Albin Sandelin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Transcriptional regulation; transcription factor binding sites; phylogenetic footprinting; pattern finding; pattern comparison;

   Sammanfattning : As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of genes is laborious and expensive, but can be substantially accelerated with the use of computational predictions. LÄS MER

3. 7. Computer-aided optimization of complex processes in production systems and urban environments

   Författare :Mikael Yamanee-Nolin; Avdelningen för kemiteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Optimization; modeling; simulation; complex processes; process systems engineering; preparative chromatography; blue-green systems;

   Sammanfattning : Complex processes can be seen as a series of actions, changes, and/or events that are related in different temporospatial manners, and thus are potentially difficult to understand. Optimizing such a process is therefore not necessarily a simple feat, and doing it experimentally may become both time-consuming and expensive. LÄS MER

4. 8. Mathematical Modeling of Biofilms: Theory, Numerics and Applications

   Författare :Erik Alpkvist; Matematik LTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mathematical modeling; Mathematics; conservation laws; biofilm; Matematik;

   Sammanfattning : A biofilm is a complex and diverse aggregation of microorganisms at surface comprised of among different things a protective adhesive matrix of extracellular polymeric substance. Biofilm research represents a broad range of sciences joining efforts within an interdisciplinary field of research. LÄS MER

5. 9. Experimental and computational investigation of affinity and selectivity factors in CYP2D6 and CYP3A4 mediated metabolism

   Författare :Britta Bonn; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; in vitro metabolism; biotransformation; computational modeling; drug design;

   Sammanfattning : The assessment of ADME properties and metabolic behavior of a drug is central in drug discovery and drug design. The main target for studies of metabolic properties is the Cytochrome P450 (CYP), which is responsible for the metabolism of a majority of drugs on the market and consequently also involved in many drug-drug interactions. LÄS MER

7. 10. Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects

   Författare :David D. Khan; Lena Friberg; Hartmut Derendorf; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Pharmacokinetics; Pharmacodynamics; PKPD modeling; ciprofloxacin; colistin; E. coli; antibiotics; time-kill experiments; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. LÄS MER