Sökning: "immunotherapy"

Visar resultat 21 - 25 av 288 avhandlingar innehållade ordet immunotherapy.

1. 21. Effect of allergen specific immunotherapy on allergic inflammation in the upper and lower airways

   Författare :Monica Arvidsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; birch pollen allergy; cat allergy; specific immunotherapy; rush immunotherapy; experimental allergen challenge; late asthmatic response;

   Sammanfattning : Experimental allergen challenge is widely used in diagnostic practice and research in allergy, but its relationship to environmental exposures is not clarified. Both models of allergic diseases have been used in order to examine the effects of allergen specific immunotherapy (SIT). LÄS MER

3. 22. Vascular targeting for enhanced cancer immunotherapy

   Författare :Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

   Sammanfattning : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. LÄS MER

4. 23. On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia

   Författare :Brwa Ali Hussein; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Natural killer cells; Acute Myeloid Leukemia; immunotherapy; HDC IL-2; NKG2A; NK education; SNPs; NK activating receptors; HLA class I;

   Sammanfattning : Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. LÄS MER

5. 24. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

   Författare :Henrik Jespersen; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

   Sammanfattning : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. LÄS MER

7. 25. Immunotherapy for pancreatic cancer

   Författare :Qingda Meng; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Patients with pancreatic cancer have a short life expectancy, and only 20% of the patients diagnosed with pancreatic cancer can undergo surgery. Chemotherapy does not work well: Gemcitabine is the standard regimen with a 5-year survival rate of 1%–4% and a median survival time of 4-6 months; FOLFIRINOX chemotherapy regimen using four drugs was found to be more effective (median survival 11 months), but with substantial side effects. LÄS MER