Sökning: "immune dysregulation"

Visar resultat 1 - 5 av 80 avhandlingar innehållade orden immune dysregulation.

  1. 1. Immune dysregulation in HIV-1 infected lymphoid tissue

    Författare :Homira Behbahani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; HAART; cytokines; chemokines; lymphoid tissue; perforin; Nef; LIF; placenta; chemokine receptor;

    Sammanfattning : Lymphoid compartments are major sites for HIV-1 replication. We evaluated cytokines, chemokines and immunological effector function at the single cell level in lymphoid tissues in chronically HIV-1 infected patients. LÄS MER

  3. 2. Immune dysregulation in early life and risk of autism

    Författare :Martin Brynge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background The notion of immune perturbations in autism is in part based on numerous observations of an association between maternal infections in general during pregnancy and autism in the child, and on observations of immune abnormalities in individuals diagnosed with autism. Maternal infections during pregnancy are linked to autism in several epidemiological studies, although genetic/familial confounding has rarely been considered. LÄS MER

  4. 3. Liver Transplantation-associated Food Allergy and Eosinophilic Gastrointestinal Inflammation in Children - Clinical and Immunological Aspects

    Författare :Timo Käppi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; liver transplantation; food allergy; autoantibody; immune dysregulation; collagenous gastritis; eosinophilic esophagitis; eosinophilic inflammation; eosinophil; children;

    Sammanfattning : This thesis focuses on three recently described childhood-onset gastrointestinal disorders: liver transplantation-associated food allergy (LTFA), collagenous gastritis (CG) and eosinophilic esophagitis (EoE). Its aim was to gain additional understanding of both the clinical disease characteristics and the associated immunological aberrations in these conditions. LÄS MER

  5. 4. Aspects of immune activation in HIV-1 infection

    Författare :Piotr Nowak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :immune activation; HMGB1; PHI; HIV-1 LTR-transcription; cytokines; chemokines;

    Sammanfattning : Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under antiretroviral therapy (ART). LÄS MER

  7. 5. Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases

    Författare :Anton Sendel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, autoimmunity, and cancer. The cytoskeleton is essential for several important immune cell functions, including proliferation, movement, signaling, and vesicle trafficking. LÄS MER