Sökning: "il-1ra"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet il-1ra.

  1. 1. The role of caspase-1, caspase-4, NLRP3 and IL-1RA in bladder epithelial cells infected by uropathogenic Escherichia coli

    Författare :Anna Lindblad; Isak Demirel; Manisha Yadav; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract infection; inflammasome; uropathogenic Escherichia coli; NLRP3; caspase-1; caspase-4; IL-1RA; antimicrobial peptides; estrogen;

    Sammanfattning : Urinary tract infection is one of the most common infections and is mostlycaused by uropathogenic Escherichia coli (UPEC). The inflammasomeassociatedproteins caspase-1, caspase-4 and NLRP3 are essential in the hostcell response during urinary tract infection by regulating IL-1β release. LÄS MER

  3. 2. Gender differences in perinatal morbidity and long term consequences of preterm birth

    Författare :Emma Elsmén; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; morbidity; neonatal; gender; IL-1ra; salivary cortisol; blood pressure; circulatory; mortality; obstetrical complications; ventilatory twins;

    Sammanfattning : Newborn male infants have higher morbidity and mortality than female infants. Male fetal gender is associated with an overall increased risk of preterm birth and complications related to pregnancy are overrepresented in women carrying male fetuses. LÄS MER

  4. 3. Molecular determinants of disease severity in urinary tract infection

    Författare :Ines Ambite; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Asymptomatic bacteriuria; urinary tract infection; acute pyelonephritis; cystitis; Escherichia coli 83972; host response; NlpD; RNA Polymerase II; transcription regulation; inflammasome; Il-1β; ASC; NLRP-3; hyper-inflammatory disorder; MMP-7; IL-1RA; genetic susceptibility; IRF-7; siRNA therapy; P fimbriae; type 1 fimbriae;

    Sammanfattning : In the urinary tract, Escherichia coli infection may result in life-threatening disease, or asymptomatic bacterial carriage, comparable to bacterial commensalism in the gut. Pathogenic strains trigger a disease provoking host response which differs depending on the infected organ. LÄS MER

  5. 4. Role of IL-1RAcP and IL-1ra in IL-1 signalling : molecular biological and transgenic studies

    Författare :Johan Lundkvist; Alberto Mantovani; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Other chemistry; Övrig kemi;

    Sammanfattning : IL-1 is a proinflammatory cytokine which causes systemic responses such as fever, increased neuroendocrine activity, sympathetic outflow and increased immune responses. Activation of the transcription factor NFkB is one of the molecular mechanisms involved in IL-1 signalling. LÄS MER

  7. 5. Tobacco smoking and periodontal disease : some clinical, microbiological and immunological aspects

    Författare :Lennart Boström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :gingival crevicular fluid; IL-1[beta]; IL-1ra; Il-6; periodontal bone height; periodontal surgery; periodontopathogens; TNF-[alpha]; smoking;

    Sammanfattning : The main aim of the thesis was to evaluate the influence of smoking on the inflammatory response in periodontal disease. The overall study population included 347 patients: 224 men and 123 women, aged between 31-86 years, with moderate to severe periodontal disease. LÄS MER