Sökning: "igf-i"

Visar resultat 1 - 5 av 161 avhandlingar innehållade ordet igf-i.

  1. 1. Insulin and IGF-I in type 1 diabetes

    Författare :Christina Hedman; Claes-Göran Östenson; Linköpings universitet; []
    Nyckelord :Type I diabetes; IGF-I; IGF system; insulin; insulin analogues; MEDICINE; MEDICIN;

    Sammanfattning : Patients with type I diabetes have alterations in the GH/IGF system with reduced levels of circulating IGF-I, as well as other disturbances in the components of the IGF system.Alterations of both local and circulating IGF-I and its binding proteins (IGFBPs) have been associated with metabolic and vascular manifestations of diabetes and also with atherosclerosis. LÄS MER

  3. 2. Effects of GH and liver-derived IGF-I on growth and metabolism

    Författare :Klara Sjögren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GH; IGF-I; Insulin; GHRH; Somatostatin; GHS; Body growth; Body composition; Liver; Bone mineral content; Bone mineral density.;

    Sammanfattning : Growth hormone (GH) exerts major effects on body growth and metabolism. Insulin-like growth factor (IGF) is expressed in response to GH and is known to mediate many of the effects of GH. The largest expression of IGF is found in the liver although it is expressed in virtually every tissue of the body. LÄS MER

  4. 3. Life, death ant the role of IGF-I in human multiple myeloma

    Författare :Patrik Georgii-Hemming; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Multiple Myeloma; IGF-I; apoptosis; Fas; glucocorticoids; somatostatin; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant cells with a plasmablast- plasma cell morphology in the bone marrow. It is a fatal disease with a median survival of 2-3 years after start of conventional therapy. LÄS MER

  5. 4. Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I

    Författare :N David Åberg; Göteborgs universitet; []
    Nyckelord :Connexin43; rat; development; hypophysectomy; primary culture; ; mRNA; gap junction; somatotropin; IGF-I; serotonin; glutamate; ; brain region heterogeneity; calcium wave; astrocyte; astroglial cell; ; gap junctional coupling.;

    Sammanfattning : Connexins form gap junctions that are aqueous pores allowing low-molecular (.... LÄS MER

  7. 5. Proliferative and protective effects of the GH/IGF-I axis on cardiomyocytes and neural progenitor cells

    Författare :Inger Johansson; Göteborgs universitet; []
    Nyckelord :GH; IGF-I; GH secretagogues; Ghrelin; Cardiovascular; Neurogenesis; Hippocampus; Proliferation; Protection;

    Sammanfattning : Cardiovascular disease is the most common cause of mortality in the Western world and the majority of cardiovascular deaths are caused by coronary artery disease or cerebrovascular disease. Growth hormone (GH) is a growth-promoting hormone synthesized by the pituitary. LÄS MER