Sökning: "icodextrin metabolites"

Hittade 2 avhandlingar innehållade orden icodextrin metabolites.

  1. 1. Icodextrin metabolism in peritoneal dialysis : Clinical and experimental studies

    Författare :Elvia García López; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Peritoneal dialysis; icodextrin; icodextrin metabolites; ultrafiltration; alphaarnylase activity; gel-filtration HPLC;

    Sammanfattning : Icodextrin (ICO, or polyglucose) is an effective osmotic agent for peritoneal dialysis (PD) patients (pts). ICO is a soluble polymeric form of glucose with an average molecular 'weight range from 13,000 to 19,000 dalton. Glucose is absorbed from the peritoneal cavity by diffusion. LÄS MER

  2. 2. Icodextrin metabolism in peritoneal dialysis : Clinical and experimental studies

    Författare :Elvia Garcia Lopez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Icodextrin is a glucose polymer which is used as osmotic agent to provide sustained ultrafiltration (UF) during the long (8-16 hours) dwell in end-stage renal disease patients undergoing peritoneal dialysis (PD). The aims of this thesis were to study: the metabolism of icodextrin in the peritoneal cavity and in the circulation of PD patients and non-uremic rats, the role of alpha-amylase in its hydrolysis, and the rate of breakdown of a synthetic maltoheptaose (G7) ex vivo which we propose as a novel measure of amylase mediated oligosaccharide metabolism. LÄS MER