Sökning: "hypoxia-ischemia"
Visar resultat 6 - 10 av 33 avhandlingar innehållade ordet hypoxia-ischemia.
6. Caspase-dependent and caspase-independent neuronal injury in the developing brain
Sammanfattning : Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed at certain time points after hypoxia-ischemia. LÄS MER
7. Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link
Sammanfattning : Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher susceptibility to infections, which puts them at a higher risk of developing neurological impairments as well as neurodevelopmental diseases. LÄS MER
8. Developing brain and systemic inflammation: a "Toll-like" link with consequences
Sammanfattning : The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. LÄS MER
9. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
Sammanfattning : Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role, not only due to their central function in metabolism, but also because many proteins with apoptosisrelated functions are located in the mitochondrion. LÄS MER
10. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
Sammanfattning : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. LÄS MER