Sökning: "hypoxanthine"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet hypoxanthine.

  1. 1. Splanchnic organ homeostasis in experimental endotoxin shock : with special reference to the endothelin and renin-angiotensin systems

    Författare :Anders Oldner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Endotoxin; endothelin; angiotensin II shock; tonometry microdialysis; porcine; hypoxanthine; gut; splanchnic circulation; lactate; mucosal pHi;

    Sammanfattning : Splanchnic organ homeostasis may become severely deteriorated in states of sepsis and endotoxaemia. Gut tissue hypoxia with subsequent increases in intestinal mucosal permeability has been proposed to contribute to the development of multiple organ failure. LÄS MER

  2. 2. Environmental and genetic factors in lung cancer : epidemiologocal and biomolecular studies focusing on nonsmokers

    Författare :Fredrik Nyberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Lung cancer; case-control study; smoking misclassification; exposure misclassification; validation; bias; nonsmoker; smoking; environmental tobacco smoke; ETS; diet; biomarker; glutathione S transferase; GSTM1; N-acetyl transferase; NAT2; hypoxanthine-guanine phosphoribosiyl transferase; hprt; DNA; adducts;

    Sammanfattning : Tobacco smoking is the major cause of lung cancer. Other risk factors include exposure to environmental tobacco smoke (ETS), dietarv habits and genetic factors. When studying such risk factors, confounding from smoking presents a pervasive methodological problem. LÄS MER

  3. 3. Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism

    Författare :Mohammad Kavianipour; Umeå universitet; []
    Nyckelord :Ischemic preconditioning; adenosine; purine nucleoside phosphorylase; microdialysis; pig; Medicine; medicin;

    Sammanfattning : Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). LÄS MER

  4. 4. Structural and functional studies of enzymes in nucleotide metabolism : a detailed investigation of two enzymes and interaction profiling of FDA-approved nucleoside analog drugs with 23 enzymes

    Författare :Louise Egeblad; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Enzymes in nucleotide metabolism serve as the producers of the building blocks for DNA and RNA. From a medical perspective, nucleotide metabolism, and in particular salvage pathway enzymes, have attracted special interest, as nucleoside prodrugs given in the treatment of cancer and HIV are converted into their active metabolite forms by these enzymes. LÄS MER

  5. 5. Human muscle response to sprint exercise in a gender perspective

    Författare :Mona Esbjörnsson Liljedahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Anaerobic; Performance; Wingate-test; muscle biopsy; Adenine nucleotides; hormones; glycogen; type I fibres; type II fibres; fast twitch; slow twitch; muscle morphology; men; women; sprint training;

    Sammanfattning : Anaerobic performance, muscle characteristics and acute and chronic response to sprint exercise were studied in physically active healthy women (n=35; age 24) and men (n=38; age 25). The aims of the present study were to: 1) Establish if women possess lower oxidative and glycolytic capacity, higher proportion of type I fibres and smaller type II fibre areas in relation to type I fibre areas in thigh musculature than men. LÄS MER