Sökning: "hypercoagulation"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet hypercoagulation.

  1. 1. Hypercoagulation in preeclampsia : implications for maternal health and fetal growth

    Författare :Shu He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Preeclampsia (PE) is a serious complication of pregnancy characterized by hypertension, proteinuria, oedema and hypercoagulation. Damage in organs, such as the liver and kidney, is harmful to the maternal health. Impairments in placental function cause intrauterine growth retardation (IUGR). LÄS MER

  3. 2. Reproductive aspects of the protein C system in women

    Författare :Margareta Wramsby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypercoagulation; Factor V Leiden; APC resistance; Protein C inhibitor; Recurrent abortions; Menstrual cycle; Pregnancy; Controlled ovarian hyperstimulation.;

    Sammanfattning : Of great importance to the reproductive system in women are the activating and inhibiting factors which maintain haemostatic balance. These play a prominent role in the prevention of abnormal bleeding, at ovulation as well as during menstruation, pregnancy and delivery. The coagulation cascade is primarily down regulated by the protein C system. LÄS MER

  4. 3. Determination of the overall haemostasis potential and fibrin gel permeability : method development and application in research and in clinical materials

    Författare :Aleksandra Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Global haemostatic assays; overall haemostasis potential; hypercoagulation; hypocoagulation; thrombophilia; haemophilia; fibrin gel porosity; LMMH therapy; acetylsalicylic acid therapy;

    Sammanfattning : We have previously developed a laboratory method that may screen the Overall Haemostasis Potential (OHP) in plasma based on spectophotometric measurement of an area under the fibrin aggregation curve in citrated plasma samples to which tiny amounts of exogenous thrombin and tissue-plasminogen activator (t-PA) are added. When the fibrin aggregation curve is created, the fibrinogen originally present in plasma is gradually converted to fibrin by the generated thrombin. LÄS MER

  5. 4. Perioperative blood saving techniques with coagulative evaluation in orthopedic surgery

    Författare :Gustav Ekbäck; Anders Bengtsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Allogeneic blood transfusion, although often needed in major surgery with large per-and postoperative bleeding, is fraught with dangers such as clerical mishandling, immunosuppression and blood-borne infections. It is therefore important to find ways to avoid allogeneic blood transfusion by means of less bleeding, better tolerance of the bleeding or alternatives to allogeneic blood. LÄS MER

  7. 5. Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide

    Författare :Johanna S Ungerstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sepsis; endotoxin; tissue factor; cytokines; nicotinamide; coagulation; inflammation;

    Sammanfattning : In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes of morbidity and mortality in the intensive care. LÄS MER