Sökning: "hydroxysteroid 11-beta dehydrogenase 1"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden hydroxysteroid 11-beta dehydrogenase 1.

1. 1. Personality and the HPA-axis in Association with Postpartum Depression

   Författare :Stavros I Iliadis; Alkistis Skalkidou; Inger Sundström Poromaa; Erika Comasco; Sara Sylvén; Lil Träskman Bendz; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Corticotropin-releasing hormone; cortisol; HPA-axis; HSD11B1; hydroxysteroid 11-beta dehydrogenase 1; neuroticism; peripartum depression; personality; postpartum depression; rs12565406; stress; Obstetrik och gynekologi; Obstetrics and Gynaecology; Psychiatry; Psykiatri;

   Sammanfattning : Postpartum depression is a psychiatric disorder affecting a substantial proportion of newly delivered women, and remains a significant cause of childbirth-related morbidity. The aim of the present thesis was to examine psychological, endocrine and genetic aspects of postpartum depression in a large, population-based sample of women in Uppsala, Sweden. LÄS MER

3. 2. Glucocorticoid administration : studies on weight regulation and metabolic implications

   Författare :Joanna Uddén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glucocorticoids; leptin; obesity; adipose tissue; PAI-1; UCP-2; cortisol; the metabolic syndrome; 11 beta-HSD; eating behaviour; weight gain.;

   Sammanfattning : Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have been suggested to play a role in development of visceral fat accumulation. LÄS MER

4. 3. Congenital adrenal hyperplasia, CYP21 deficiency, screening and clinical aspects

   Författare :Anna Nordenström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Congenital adrenal hyperplasia; 21 -hydroxylase deficiency; CYP21; neonatal screening; 17-OHP; sex-typed behavior; toy play.;

   Sammanfattning : Congenital adrenal hyperplasia (CAH) is a group of recessively inherited disorders. More than 90% of all cases of CAB are caused by 21-hydroxylase deficiency. This enzyme deficiency results in reduced ability to synthesize cortisol and aldosterone and at the same time increased secretion of androgens. LÄS MER

5. 4. The metabolic syndrome : studies on thrifty genes

   Författare :Katja Kannisto; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adipose tissue; adiponectin; 11beta-hydroxysteroid dehydrogenase type 1; BMI; glucocorticoid; GLUT; HAART; HIV; IL-6; insulin; insulin resistance; LDL-cholesterol; leptin; lifestyle; lipodystrophy; LPL; obesity; PPAR; PGC-1; polymorphism; rosiglitazone; skeletal muscle; twins;

   Sammanfattning : The metabolic syndrome consists of a cluster of atherogenic risk factors that include insulin resistance, glucose intolerance, hyperglycemia, dyslipidemia, obesity and a procoagulant state with impaired fibrinolysis. Genetic factors might predispose to the metabolic syndrome while the increasing prevalence of visceral and abdominal obesity linked to the shift to more sedentary lifestyles exacerbates the manifestation. LÄS MER

7. 5. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

   Författare :Viveka Dolby; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

   Sammanfattning : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. LÄS MER