Sökning: "hydrophobic interaction"

Visar resultat 21 - 25 av 206 avhandlingar innehållade orden hydrophobic interaction.

  1. 21. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing

    Författare :Malin Källsten; Jonas Bergquist; Fredrik Lehmann; Sara Lind; Lucia Kovac; Alain Beck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody-drug conjugates; drug-to-antibody ratio; monoclonal antibody; mass spectrometry; hydrophobic interaction chromatography; sample preparation; aggregation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. LÄS MER

  3. 22. Modeling and Optimization of Reversed-Phase Chromatography : Effects of Modulators and Temperature

    Författare :Karolina Arkell; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reversed-phase chromatography; Hydrophobic interaction chromatography; Mechanistic modeling; INSULIN; KCl; Ethanol; Temperature; Multi-objective optimization; Constraint; Solubility;

    Sammanfattning : Many widespread diseases, such as diabetes, various types of cancer, and aggressive versions of influenza, are treated or prevented with biopharmaceuticals. Biopharmaceuticals are drugs that are based on proteins, peptides, antibodies, attenuated viruses (vaccines), and other biomolecules that are synthesized predominately in bacteria, yeast, and mammalian cells. LÄS MER

  4. 23. Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3

    Författare :Lubna Yasmin; Bengt Hallberg; Joan Olson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExoS; ADP-ribosylation; 14-3-3 protein; Pseudomonas aeruginosa; Small GTPases; RAS; RAP; Pathology; Patologi;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic pathogen that is a serious problem for immuno-compromised patients. Toxins such as exoenzyme (Exo) S, ExoT, ExoY and ExoU are secreted and translocated from the bacteria into the eukaryotic cell via the bacterial encoded type III secretion system. LÄS MER

  5. 24. Interaction of magnetite with soluble silicates and bentonite : implications for wet agglomeration of magnetite concentrate

    Författare :Xiaofang Yang; James McQuillan; Luleå tekniska universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical Chemistry; Fysikalisk kemi; Chemistry of Interfaces; Gränsytors kemi;

    Sammanfattning : Iron ore green pellets are produced by agglomeration of moist magnetite concentrates. The quality of green pellets is essential for the transportability and metallurgical benefits of the final product. LÄS MER

  7. 25. Polyester scaffold: Material design and cell-protein-material interaction

    Författare :Staffan Dånmark; Anna Finne-Wistrand; Ann-Christine Albertsson; Kamal Mustafa; Pentti Tengvall; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Tissue engineering has emerged as a valid approach for the regeneration and restoration of bone defects. The concept of bone tissue engineering includes degradable scaffolds, osteogenic cells and osteoinductive growth factors either alone or in any combination of these three. LÄS MER