Sökning: "hyaluronic acid"

Visar resultat 6 - 10 av 46 avhandlingar innehållade orden hyaluronic acid.

1. 6. Uncovering a Novel Pathway for Autoinflammation : With a Little Help from a Wrinkled Friend

   Författare :Mia Olsson; Kerstin Lindblad-Toh; Gerli Pielberg; Göran Andersson; Leif Andersson; Rikard Holmdahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoinflammation; hyaluronic acid; amyloidosis; canine model; genetic association; Molekylär genetik; Molecular Genetics;

   Sammanfattning : A major challenge in medical genetics is to identify the mutations underlying heritable diseases. Dogs are excellent genetic models in the search for causative mutations, as they constitute a large library of naturally occurring heritable diseases many of which are analogous to those suffered by man. LÄS MER

3. 7. Evaluation of Functionalized Biopolymers as a Step Toward Targeted Therapy of Osteoporosis

   Författare :Sujit Kootala; Jöns Hilborn; Peter Thomsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Osteoporosis; Bone regeneration; Biomaterials; Hyaluronic acid; Bisphosphonates; Osteoclasts; Osteoblasts; Growth factors; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

   Sammanfattning : The work presented in this thesis focuses on the development of strategies and smart bioactive materials for the treatment of osteoporosis. High and low molecular weight soluble hyaluronic acid-bisphosphonate (HA-BP) derivatives were investigated for their ability to inhibit osteoclasts. LÄS MER

4. 8. Development and characterization of an in vitro method for interaction studies between polymers and pharmaceuticals : Aiding in the development of new drug delivery systems

   Författare :Marcus Wanselius; Per Hansson; Magnus Bergström; Susanna Abrahmsén-Alami; Christian Pedersen; Anna Fureby; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microgels; Subcutaneous administration; Drug delivery; Microfluidics; In vitro methodology; Method development; Biopharmaceuticals; Amphiphilic drugs; Polyelectrolytes; Hyaluronic acid; Peptides; Farmaceutisk fysikalisk kemi; Pharmaceutical Physical Chemistry;

   Sammanfattning : Polymers are a group of macromolecules used in formulations of pharmaceuticals, one example being the delivery system DC Bead™. Further, some of the most abundant and for drug delivery important constituents of the subcutaneous tissue are charged polymers (polyelectrolytes), e.g. collagen, hyaluronic acid, and chondroitin sulfate. LÄS MER

5. 9. Insights into Covalent Chemistry for the Developmen­t of Biomaterials

   Författare :Daniel Bermejo-Velasco; Oommen P. Varghese; Jöns Hilborn; Frey Holger; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronic acid; hydrogel; biomaterials; covalent chemistry; biomedical applications; MRI; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

   Sammanfattning : Covalent cross-linking chemistry is currently exploited in the preparation of biomaterial for biomedical applications. Choice of these chemistries for the preparation of biomaterials and bioconjugates strongly influences the biological output of these materials. LÄS MER

7. 10. Circulating proteoglycans and glycosaminoglycans during critical illness

   Författare :Axel Nelson; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulphate; glycocalyx; hyaluronic acid; syndecan; permeability; antimicrobial;

   Sammanfattning : The endothelial glycocalyx is the carbohydrate rich inner layer of the blood vessels. Important components of the glycocalyx are the proteoglycans with their attached glycosaminoglycans. LÄS MER