Sökning: "hutchinson-gilford progeria syndrome"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden hutchinson-gilford progeria syndrome.

  1. 1. Molecular studies of Hutchinson-Gilford progeria syndrome

    Författare :Hanna Sagelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disease, with an incidence of 1 in 4-8 million live births, that causes segmental premature aging in children. The children look normal at birth but begin to develop symptoms of disease within the first years of life. LÄS MER

  3. 2. Epithelial stem cells in Hutchinson-Gilford progeria syndrome

    Författare :Tomás McKenna; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which occurs at around 13 years of age. LÄS MER

  4. 3. Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice

    Författare :Charlotte Strandgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet completely understood. Studies of premature aging syndromes might be helpful to acquire further clues to understand the molecular mechanisms explaining how aging occurs. LÄS MER

  5. 4. The genetic mechanism that links Hutchinson-Gilford progeria syndrome to physiological aging

    Författare :Sofía Rodríguez Vásquez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aging is a complex process that is not completely understood. The study of segmental progeroid syndromes such as Hutchinson-Gilford progeria syndrome (HGPS) has allowed us to connect the common genetic mechanisms that occur in normal physiological aging, with the cellular alterations presented by this severe premature aging syndrome. LÄS MER

  7. 5. Mouse models for understanding the molecular mechanism of bone disease in Hutchinson-Gilford progeria syndrome

    Författare :Eva Schmidt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aging is a complex process affecting all people. Intense research is applied to elucidate the biological basis of aging and disease that develop with aging. Studies of progeroid syndromes, where aging happens in an accelerated speed, might be useful to understand the molecular mechanisms in physiological aging. LÄS MER