Sökning: "human plasma"

Visar resultat 11 - 15 av 911 avhandlingar innehållade orden human plasma.

1. 11. Affinity assays for profiling disease-associated proteins in human plasma

   Författare :Sanna Byström; Jochen M. Schwenk; Claudia Fredolini; Peter Nilsson; Jennifer Van Eyk; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; immuno-capture; plasma; serum; cerebrospinal fluid; biomarker discovery; multiple sclerosis; malignant melanoma; mammographic breast density; Bioteknologi; Biotechnology;

   Sammanfattning : Affinity-based proteomics offers opportunities for the discovery and validation of disease-associated proteins in human body fluids. This thesis describes the use of antibody-based immunoassays for multiplexed analysis of proteins in human plasma, serum and cerebrospinal fluid (CSF). LÄS MER

3. 12. Multi-platform metabolomics assays to study the responsiveness of the human plasma and lung lavage metabolome

   Författare :Masoumeh Karimpour; Malin Nording L.; Magnus Åberg; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LC MS; GC MS; NMR; metabolomics; metabolite; exposure; postprandial; plasma; lung lavage; BW; BW; data analysis; univariate analysis; multivariate analysis;

   Sammanfattning : Metabolomics as a field has been used to track changes and perturbations in the human body by investigating metabolite profiles indicating the change of metabolite levels over time and in response to different challenges. In this thesis work, the main focus was on applying multiplatform-metabolomics to study the human metabolome following exposure to perturbations, such as diet (in the form of a challenge meal) and exhaust emissions (air pollution exposure in a controlled setting). LÄS MER

4. 13. Studies of Cellular Regulatory Mechanisms : from Genetic Switches to Cell Migration

   Författare :Maria Werner; Erik Aurell; Ulrich Gerland; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasma physics; Plasmafysik;

   Sammanfattning : Cellular behaviour depends ultimately on the transcription of genes. If we know how transcription is controlled we have a better chance of understanding cellular processes. This thesis presents six studies, all concerning cellular regulatory mechanisms. One study is purely experimental and five are computational studies. LÄS MER

5. 14. Structure and organization of genes for the predominant seminal plasma proteins semenogelin I, semenogelin II and beta-microseminoprotein

   Författare :Magnus Ulvsbäck; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; transglutaminase substrate; semen coagulation; prostate; seminal vesicles; seminal plasma; rhesus monkey; human; evolution; nucleic acid sequence; cDNA; gene; semenogelin; b-microseminoprotein; Klinisk kemi; Proteins; enzymology; Proteiner; enzymologi;

   Sammanfattning : In man, the predominant proteins in the seminal plasma include semenogelin I, semenogelin II and b-microseminoprotein (MSP). Semenogelin I and II are both synthesized in the seminal vesicles and are the backbone of the gel formed upon semen coagulation. MSP is synthesized in the prostate, but its role has not yet been defined. LÄS MER

7. 15. Human Glandular Kallikrein 2

   Författare :Janita Lövgren; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; seminal plasma; semenogelin; PCI; serpin; zinc; cancer; prostate; PSA; hK2; serine protease; kallikrein; Clinical chemistry; Klinisk kemi;

   Sammanfattning : Human glandular kallikrein 2 (hK2) is a serine protease, which is predominantly expressed by the prostate gland and found in seminal plasma at mean levels of 6 mg/ml. It has 79% amino acid sequence identity with prostate-specific antigen (PSA or hK3). LÄS MER