Sökning: "human hepatoma cells HepG2"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden human hepatoma cells HepG2.

  1. 1. Single-Proton Irradiation of Living Cells - Development of New Tools for Low-Dose Radiation Research

    Författare :Natalia Arteaga; Kärnfysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; lithography; UVL; EBL; SeACell; human hepatoma cells HepG2 ; reactive oxygen species ROS ; bystander effect; SU-8; cell recognition; cell irradiation; Single-Ion Hit Facility; low-dose; Fysicumarkivet A:2010:Arteaga Marrero;

    Sammanfattning : A Single-Ion Hit Facility (SIHF) consists of a custom-build facility based in particle accelerators which offers irradiation controlling the number of delivered particles with a precise targeting localization. The irradiation spot can be confined down to the nanometre scale allowing the irradiation of subcellular compartments with a single particle. LÄS MER

  3. 2. Translational genetics identifies a novel target to treat fatty liver disease

    Författare :Kavitha Sasidharan; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty liver disease; human genetics; GWAS; PSD3; spheroids;

    Sammanfattning : Fatty liver disease (FLD) is rapidly prevailing as the most common liver disease worldwide, with an estimated of one-quarter of the global population affected. Environmental and genetic determinants contribute to FLD susceptibility. LÄS MER

  4. 3. Genetic and metabolic studies of APOE, PCSK9, TM6SF2 and PNPLA3

    Författare :Hovsep Mahdessian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipids – including fatty acids (FAs), triglycerides (TGs), cholesterol and cholesterol esters (CEs) – are hydrophobic molecules involved in several important structural and mechanistic processes. Lipids are found in cellular membranes, give posture and stability to the cell, are actively participating in cellular signaling, and act as mediators in several important biological pathways. LÄS MER

  5. 4. Identification and functional characterization of proteins involved in hepatic triglyceride metabolism

    Författare :Apostolos Taxiarchis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Triglycerides are the main form of energy in the tissues and liver, along with the adipose tissue, is the main organ of triglyceride metabolism and storage in the lipid-droplet organelles. A number of proteins are involved in the regulation of the triglyceride metabolism in human liver, however their specific role is still not thoroughly known. LÄS MER

  7. 5. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

    Författare :Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

    Sammanfattning : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. LÄS MER