Sökning: "human hepatocytes"

Visar resultat 16 - 20 av 80 avhandlingar innehållade orden human hepatocytes.

  1. 16. Novel human in vitro systems for studies of drug inducted hepatotoxicity

    Författare :Louise Sivertsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug discovery, being one of the most common reasons for regulatory actions, including boxed warnings, restricted marketing and withdrawals of marketed drugs. LÄS MER

  3. 17. Human amnion epithelial stem cells as a therapy for liver disease

    Författare :Raghuraman Chittoor Srinivasan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Placenta-derived stem cells have been proposed as potential new treatments for acute and congenital liver diseases. Of all the different perinatal tissues, amnion membrane and isolated amnion epithelial cells have been shown to be an outstanding readily available source of multipotent stem cells. LÄS MER

  4. 18. Human liver in vitro models for evaluation of drug metabolism and disposition

    Författare :Malin Darnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The administrated dose of a drug is adjusted to give a therapeutic effect in patients without causing side-effects or toxicity. Cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes, uptake and efflux transporters and nuclear receptors regulating these enzymes, expressed in the liver and in other tissues, are all important players in drug metabolism, disposition and elimination. LÄS MER

  5. 19. Studies on the molecular regulation of bile acids and lipoproteins in human liver

    Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only organ capable of a quantitative elimination of cholesterol from the body. LÄS MER

  7. 20. Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo

    Författare :Kajsa P Kanebratt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytochrome P450 (P450) enzymes comprise the most important enzyme system with regard to phase I metabolism of drugs. Induction of P450s can result in decreased plasma concentrations of the drug itself or a coadminstered drug, followed by lack of effect. LÄS MER