Sökning: "human genetic diversity"

Visar resultat 1 - 5 av 106 avhandlingar innehållade orden human genetic diversity.

  1. 1. Population Genetic Methods and Applications to Human Genomes

    Författare :Lucie Gattepaille; Mattias Jakobsson; Kevin Thornton; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Population genetics; Human evolution; Genetic diversity; Genetic differentiation; Adaptation; Population structure; Effective population size; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Population Genetics has led to countless numbers of fruitful studies of evolution, due to its abilities for prediction and description of the most important evolutionary processes such as mutation, genetic drift and selection. The field is still growing today, with new methods and models being developed to answer questions of evolutionary relevance and to lift the veil on the past of all life forms. LÄS MER

  3. 2. Human demographic history : Insights on the human past based on genomes from Southern through Central Africa

    Författare :Gwenna Breton; Mattias Jakobsson; Carina Schlebusch; Per Sjödin; Paul Verdu; David Comas; Uppsala universitet; []
    Nyckelord :high-coverage genomes; Sub-Saharan Africa; demography; genetic admixture; population genetics; human evolutionary genetics; Khoe-San; rainforest hunter-gatherers; Biology with Specialisation in Human Evolution and Genetics; Biologi med inriktning mot människans evolution och genetik;

    Sammanfattning : Evidence from paleontology, archaeology and population genetics support that modern humans originated in Africa. While the out-of-Africa event and subsequent colonization of all continents are well documented, human history in Africa at that time and before is less studied. LÄS MER

  4. 3. Genetic studies of two inherited human phenotypes : Hearing loss and monoamine oxidase activity

    Författare :Jorune Balciuniene; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; linkage analysis; hearing loss; digenic inheritance; allelic association; monoamine oxidase; human genetic diversity; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : This thesis focuses on the identification of genetic factors underlying two inherited human phenotypes: hearing loss and monoamine oxidase activity. Non-syndromic hearing loss segregating in a Swedish family was tested for linkage to 13 previously reported candidate loci for hearing disabilities. LÄS MER

  5. 4. Assessing and monitoring genetic patterns for conservation purposes with special emphasis on Scandinavia

    Författare :Anna Palmé; Nils Ryman; Linda Laikre; Kerry Naish; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological diversity; conservation genetics; management unit; spatial genetic structure; sympatric populations; genetic monitoring; release of alien populations; northern pike; brown trout; harbour porpoise; Biology; Biologi; populationsgenetik; Population Genetics;

    Sammanfattning : Genetic variation is essential for biological evolution, for maintaining viability of populations, and to ensure ecosystem resilience. Increased human exploitation and environmental change result in rapid loss of biological variation, including genetic diversity. LÄS MER

  7. 5. Genetic and Epigenetic Variation in the Human Genome : Analysis of Phenotypically Normal Individuals and Patients Affected with Brain Tumors

    Författare :Cecilia De Bustos; Jan P. Dumanski; Joseph F. Costello; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; genetic variation; epigenetics; brain tumor; array-CGH; glioblastoma; ependymoma; microarray; methylation; Genetik; Genetics; Genetik;

    Sammanfattning : Genetic and epigenetic variation is a key determinant of human diversity and has an impact on disease predisposition. Single nucleotide polymorphisms (SNPs) and copy number polymorphisms (CNPs) are the main forms of genetic variation. The challenge is to distinguish normal variations from disease-associated changes. LÄS MER