Sökning: "human embryonic stem cell"

Visar resultat 1 - 5 av 152 avhandlingar innehållade orden human embryonic stem cell.

1. 1. Human embryonic stem cells for bone engineering applications

   Författare :Giuseppe Maria de Peppo; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human skeleton; bone; bone defects; bone regeneration; regenerative medicine; tissue engineering; biomaterials; scaffold; biocoral; titanium; osseointegration bioreactor; human stem cells; embryonic stem cells; mesenchymal stem cells; embryonic-derived progenitors; osteogenic differentiation; mineralization; immune response; in vitro; in vivo;

   Sammanfattning : The human skeleton represents the supporting structure of the organism and accounts for about 20 percent of the total body mass. Despite its intrinsic capacity to regenerate and self-repair, this ability is limited and repair therapies are needed in a large number of clinical cases. LÄS MER

3. 2. Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation

   Författare :Dzeneta Vizlin-Hodzic; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Oct4; SAF-A; Brg1; Tpt1; Npm1; transcriptional regulation; cell proliferation; shelterin;

   Sammanfattning : Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene expression, high telomerase activity and specific cell proliferation, characteristics shared with cancer stem cells. LÄS MER

4. 3. Towards Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells

   Författare :Roger Rönn; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; pluripotent stem cells; embryonic development.; in vitro differentiation;

   Sammanfattning : There is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. LÄS MER

5. 4. Transcriptional profiling of human embryonic stem cells and their functional derivatives

   Författare :Jane Synnergren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcription; differentiation; human embryonic stem cells; gene expression; Naturvetenskap;

   Sammanfattning : Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. Based on these properties, hESCs and their derivatives provide unique model systems for basic research on embryonic development. LÄS MER

7. 5. Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem Cells

   Författare :Carolina Guibentif; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human pluripotent stem cells; Embryonic Development; endothelial-to-hematopoietic transition; Hematopoiesis;

   Sammanfattning : The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. LÄS MER