Sökning: "human diploid fibroblasts"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden human diploid fibroblasts.

1. 1. Studies on mutagenesis by ethylene oxide and styrene oxide in the hprt gene in human cells

   Författare :Tatiana Bastlova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ethylene oxide; styrene; styrene-7; 8-oxide; human diploid fibroblasts; human T-lymphocytes; hprt mutation;

   Sammanfattning : Environmental, occupational and life style-related exposures to mutagenic agents may contribute to cancer risk in humans. To prevent the potentially hazardous effects of such agents it is important to understand their mechanisms of action. LÄS MER

3. 2. Studies on 7a-hydroxycholesterol in extrahepatic tissues and cells

   Författare :Jie Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In human liver, primary bile acids are synthesized from cholesterol via the well-established neutral and also via the recently described acidic pathways. The latter includes 27-hydroxycholesterol 7alpha-hydroxylase. LÄS MER

4. 3. Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246

   Författare :Jinfeng Shen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in cell cycle arrest, senescence, apoptosis, etc. Mutations in p53 occur frequently (around 50%) in many human tumors. LÄS MER

5. 4. Molecular mechanisms of growth suppression by pharmacologically activated p53

   Författare :Elisabeth Hedström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer development. The importance of p53 tumor suppression function is highlighted by the fact that the p53 pathway is inactivated in most, if not all cancers. LÄS MER

7. 5. Centrosome aberrations and tumor development

   Författare :Kaoru Fujioka; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Centrosome; cervical carcinoma; adrenocortical tumor; tetraploidization; p53; griseofulvin; 13-cis-retinoic acid.;

   Sammanfattning : The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and transactivators of genes of importance for cell cycle progression. In the present thesis, the focus is on an important function that controls the segregation of the chromosomes during cell division to the next generation of two daughter cells. LÄS MER