Sökning: "human cytomegalovirus"

Visar resultat 21 - 25 av 55 avhandlingar innehållade orden human cytomegalovirus.

  1. 21. Human cytomegalovirus : development of resistance to antiviral drugs and mechanisms of NK-cell evasion

    Författare :Mehrdad Mousavi-Jazi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the herpesviridae, is ubiquitous and causes persistent infections mostly without any clinical symptoms. However, HCMV infection is a major cause of morbidity and mortality among immunocompromised patients, especially transplant recipients and patients with AIDS. LÄS MER

  3. 22. Specific T- and B-cell responses against human cytomegalovirus after hematopoietic stem cell transplantation

    Författare :Lena Catry; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human cytomegalovirus (CMV) remains an important complication in allogeneic hematopoietic stem cell transplantation (HSCT). CMV-reactivation may lead to CMV-disease associated with high morbidity and mortality in patients after HSCT. LÄS MER

  4. 23. Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?

    Författare :Michel Silvestri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CMV; HCMV; gB; autoimmunity; cross-reactivity; epitope analysis electrochemiluminescence; heparin; heparan sulphate; neutralising antibodies;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a significant factor in morbidity, why there is clearly a need for effective therapy and prophylaxis against HCMV infection. LÄS MER

  5. 24. Human cytotoxic lymphocyte differentiation in health and disease

    Författare :Heinrich Schlums; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory cytokines and chemokines. NK cells and CD8+ T cells belong to different arms of the immune system, employing complementary strategies for target cell recognition. LÄS MER

  7. 25. Cytomegalovirus infection in vascular diseases and transplant rejection

    Författare :Mensur Dzabic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human cytomegalovirus (HCMV) infects 60-100% of the adult population. It belongs to the Herpesviridae family and establishes latency within its host post primary infection. HCMV reactivation is dependent on inflammation and the virus has evolved numerous mechanisms to sustain an inflammatory process and thus prolong its replication period. LÄS MER