Sökning: "human class switched antibodies"

Hittade 2 avhandlingar innehållade orden human class switched antibodies.

  1. 1. Studies of T- and B-cells for the generation of human antigen specific antibodies

    Författare :Eva Andersson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; germinal center; CD4 CD57 T cells; mucin 1; in vitro immunization; human class switched antibodies; Biotechnology; Bioteknik;

    Sammanfattning : Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. LÄS MER

  3. 2. Impairment of B cell trafficking and differentiation during HIV-1 infection

    Författare :Vu Phuong Linh Dang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased number of memory B cells, increased levels of activation markers on B cell surface and plasmacytosis. LÄS MER