Sökning: "human cancer risk"

Visar resultat 1 - 5 av 400 avhandlingar innehållade orden human cancer risk.

1. 1. Cancer and Inflammation : Role of Macrophages and Monocytes

   Författare :Alexander Hedbrant; Jonny Wijkander; Dick Delbro; Ann Erlandsson; Anita Sjölander; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M1 macrophages; M2 macrophages; colon cancer; lung cancer; prostaglandin E2; Biomedical Sciences; Biomedicinsk vetenskap;

   Sammanfattning : Macrophages are cells of the innate immune system that can be found in large quantities in cancer tumors and affect cancer progression by regulating growth and invasiveness of cancer cells. There are two main phenotypes of macrophages denoted M1 and M2. LÄS MER

3. 2. Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds

   Författare :Jenny Aasa; Margareta Törnqvist; Elaine M. Faustman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glycidol; 3-monochloropropane-1; 2-diol 3-MCPD ; genotoxicity; mutations; micronuclei; hemoglobin adducts; in vivo dose; multiplicative risk model; cancer risk assessment; human cancer risk; miljökemi; Environmental Chemistry;

   Sammanfattning : Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glycidol, which is genotoxic and an animal carcinogen. It is the model compound of this work, partly due to its presence in food. LÄS MER

4. 3. Wnt-5a Signalling in Human Mammary Cells: Implications for the Development of Breast Cancer

   Författare :Marzieh Jönsson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; signalling; breast cancer; Wnt-5a; mammary epithelial cells; cancer; onkologi; Cytologi; cancerology;

   Sammanfattning : The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. LÄS MER

5. 4. Regulation and Function of the Human Leukotriene D4 Receptor CysLT1 in Epithelial Cells and Colon Cancer

   Författare :Christian Kamp-Nielsen; Malmö Experimentell patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; Inflammation; PKC; Calcium; CysLT1R; GPCR; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

   Sammanfattning : The pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. LÄS MER

7. 5. Genetic characterization of malignant melanoma and breast cancer

   Författare :Göran B Jönsson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

   Sammanfattning : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. LÄS MER