Sökning: "human breast cancer"

Visar resultat 1 - 5 av 268 avhandlingar innehållade orden human breast cancer.

  1. 1. Methods for selection and optimisation of radiotherapy and early therapy evaluation in breast cancer

    Författare :Tomas Jansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Breast cancer; human; radiotherapy; multi-leaf collimator; breast-conservingsurgery; local recurrence; p53; positron emission tomography; chemotherapy evaluation; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : Adjuvant systemic therapy for breast cancer, the most common malignancy in females, increases survival and this has recently also been demonstrated for postoperative radiotherapy. The aims of this study were to develop an optimised radiotherapeutic technique for postoperative treatment, to analyse the association between p53 status in node-negative patients and radiotherapy, to investigate the incidence of in-breast relapses after conservative surgery and radiotherapy and to determine if positron emissiontomography could be useful for early evaluation of polychemotherapy. LÄS MER

  3. 2. Immune Tolerance Mechanisms in Human Breast Cancer

    Författare :Meliha Mehmeti; Malmö Cancerimmunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Immune tolerance; Toll-like receptors; DAMP; Wnt5a; TAMP; Myeloid-derived suppressor cells; Autoimmune regulator;

    Sammanfattning : .... LÄS MER

  4. 3. Clinical significance of immunohistochemistry in breast cancer diagnostics

    Författare :Slavica Janeva; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer biomarkers; immunohistochemistry; surrogate subtype; RT- qPCR; multifocal breast cancer; lymph node metastasis; triple-negative breast cancer; older women;

    Sammanfattning : For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki67. LÄS MER

  5. 4. Wnt-5a Signalling in Human Mammary Cells: Implications for the Development of Breast Cancer

    Författare :Marzieh Jönsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; signalling; breast cancer; Wnt-5a; mammary epithelial cells; cancer; onkologi; Cytologi; cancerology;

    Sammanfattning : The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. LÄS MER

  7. 5. Genetic characterization of malignant melanoma and breast cancer

    Författare :Göran B Jönsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

    Sammanfattning : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. LÄS MER