Sökning: "human T-cells"

Visar resultat 6 - 10 av 521 avhandlingar innehållade orden human T-cells.

1. 6. Migration on extracellular matrix surface and infiltration into matrix - two distinguishable activities of human T cells

   Författare :Jyrki Ivanoff; Karl-Gösta Sundqvist; Joachim Lundahl; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; extracellular matrix; fibronectin; collagen type IV; laminin; neuropeptide; chemokine; TIMP-1; MMP-9; T cells; Migration; Immunologi; Immunology; Immunologi; Clinical Immunology; klinisk immunologi;

   Sammanfattning : Migration of T-lymphocytes on a surface coated with extracellular matrix (ECM) components (two-dimensional (2-D) migration) and migration (infiltration) into a matrix (Three-dimesional (3-D) migration) are complex events and the underlying mechanisms are not yet fully understood. Here 2-D and 3-D migration were studied by use of seven leukemic T-cell lines representing discrete differentiation stages, a non-leukemic T-cell clone, and normal peripheral blood T cells. LÄS MER

3. 7. CAR T cells for Immunotherapy of Cancer

   Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

4. 8. Phenotype and function of CD25+ regulatory T cells in infants and adults

   Författare :Hanna Grindebacke; Göteborgs universitet; []
   Nyckelord :Immunology; CD4 CD25 FOXP3 regulatory T cells; human; allergy; IL-10; Systemic immunotherapy; migration; homing receptors; maturation;

   Sammanfattning : Active suppression by CD4+CD25+FOXP3+ regulatory T cells (Treg) is essential for the maintenance of peripheral tolerance to both self antigens and environmental antigens. Absence of these cells in human newborns leads to autoimmune and inflammatory disorders as well as allergic disease. LÄS MER

5. 9. Infection induced chronic inflammation and it's association with prostate cancer initiation and progression

   Författare :Sabina Davidsson; Ove Andrén; Bo Söderquist; Jennifer Rider; Gisela Helenius; Jan-Erik Damber; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; chronic inflammation; CD4 helper T cells; CD8 cytotoxic T cells; regulatory T cells; Propionibacterium acnes; Medicine; Medicin;

   Sammanfattning : An association between cancer development and inflammation has long been suggested. Approximately 20% of all human cancers in adults are assumed to result from chronic inflammation. The aim of this thesis was to investigate if infection-induced chronic inflammation plays a role in prostate carcinogenesis. LÄS MER

7. 10. Therapeutic dendritic cell vaccination against human papillomavirus

   Författare :Merja Nurkkala Karlsson; Göteborgs universitet; []
   Nyckelord :human papillomavirus; therapeutic dendritic cell vaccination; cholera toxin; T cells; TLRs and CpG;

   Sammanfattning : Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually. The two currently available HPV vaccines can only be used prophylactically, so they are of no use to the 291 million women who are already infected and at risk of developing cancer. LÄS MER