Sökning: "hsp70"

Visar resultat 21 - 25 av 41 avhandlingar innehållade ordet hsp70.

  1. 21. Induction of the heat-shock response by misfolded proteins

    Författare :Anna E. Masser; Claes Andréasson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Cells respond to stress by transcriptional changes intended for stress survival and adaption to further stresses. Heat shock is an intensively studied stress condition that induces in a plethora of physiological changes including increased protein misfolding. LÄS MER

  3. 22. Frk/Shb Signalling in Pancreatic Beta-cells : Roles in Islet Function, Beta-cell Development and Survival as Implicated in Mouse Knockout Models

    Författare :Björn Åkerblom; Michael Welsh; Hindrik Mulder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : The adaptor protein Shb and the non-receptor tyrosine kinase Frk have been implicated in intracellular signalling in insulin-producing beta cells. In this thesis, knockout mice are used to further elucidate the role of Shb and Frk for beta cell number, cytokine-induced cell death, and glucose homeostasis. LÄS MER

  4. 23. Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins

    Författare :Markus Karlsson; Christina Frennesson; Sven Erik Nilsson; Tino Kurz; Ulf Brunk; Anders Kvanta; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Oxidative stress is a major pathogenic factor in the development of age-related macular degeneration (AMD), which is the most common cause of severe central visual impairment in the elderly population in the western world.It is believed that the degenerative process starts in the retinal pigment epithelium (RPE). LÄS MER

  5. 24. Heat shock proteins in exercised human skeletal muscle

    Författare :Mattias Folkesson; Fawzi Kadi; Britta Wåhlin-Larsson; Robert Kruse; Barbara Wessner; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endurance training; Resistance training; Muscle Fibre Type; Electrical Pulse Stimulation; Muscle Hypertrophy;

    Sammanfattning : Exercise is considered as an important stressor accompanied by concerted molecular and cellular changes leading to adaptations at the level of skeletal muscle size and function. An important protein family produced by cells in response to stressful conditions is the heat shock proteins (HSPs). LÄS MER

  7. 25. Mast Cells as Sentinels : Role of serglycin and mast cell proteases in infection and inflammation

    Författare :Ananya Roy; Magnus Åbrink; Olaf Utermöhlen; Uppsala universitet; []
    Nyckelord :mast cells; serglycin; chymase; infection; parasite; Immunologi; Immunology;

    Sammanfattning : Mast cells (MCs), normally classified into connective tissue MCs and mucosal MCs, are highly granulated cells found in the interface between the interior and the exterior environment of our body, e.g. skin, airways and gastro-intestinal tract. LÄS MER