Sökning: "hr doktorsavhandling"
Visar resultat 6 - 10 av 476 avhandlingar innehållade orden hr doktorsavhandling.
6. Nanofluidics for Static and Dynamic DNA-Protein Interaction Studies - Repair of Double-Strand Breaks from a Single-Molecule Perspective
Sammanfattning : Double-strand breaks (DSBs) is one of the most lethal forms of DNA damage. A single DSB may result in stalling of vital cellular machineries, and thus, requires immediate measures by the cell. LÄS MER
7. Young adults with childhood-onset inflammatory bowel disease - aspects of bone mineral density, body composition and physical exercise
Sammanfattning : Background: Our research group has previously shown that low bone mineral density (BMD) is common in children and adolescents with inflammatory bowel disease (IBD). However, there is limited knowledge on the development of BMD and body composition traits (skeletal muscle and body fat) in early adulthood in this patient group. LÄS MER
8. New diagnostic and prognostic methods to improve the effectiveness of cervical cancer screening
Sammanfattning : This thesis has made use of real-life clinical practice to provide guidance for secondary prevention of cervical cancer. We combined epidemiological, virological and biostatistical investigations using HPV DNA and HPV E6/E7 mRNA tests in women who were identified with abnormal findings through the organised cervical cancerscreening programme. LÄS MER
9. Genomic rearrangements at the cause of three genetic disorders in man
Sammanfattning : Genomic rearrangements are a common cause of genetic disorders in man. This thesis describes the analysis of genomic rearrangements observed in patients with the Hunter syndrome (MPS II), incontinentia pigmenti (IP) and the Blepharophimosis, ptosis and epicanthus inversus syndrome (BPES). MPS II is an X-linked recessive lysosomal storage disorder. LÄS MER
10. Glucotoxicity in Insulin-Producing β-Cells
Sammanfattning : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. LÄS MER