Sökning: "host genetic and detection methods"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden host genetic and detection methods.

  1. 1. Pediatric rotavirus and norovisrus diarrhea in Nicaragua

    Författare :Filemón Bucardo-Rivera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rotavirus; Norovirus; mutations; genetic diversity; host genetic and detection methods;

    Sammanfattning : Diarrheal diseases are still one of the major health problems in developing countries with rotavirus (RV) being the most important pathogen of severe diarrhea in young children. Norovirus (NoV), a common cause of gastroenteritis is now recognized as an important cause of sporadic diarrhea and hospitalization in children worldwide. LÄS MER

  3. 2. Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis

    Författare :Karolina S. Jabbar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucus; Mass spectrometry; MUC2; MUC5AC; IPMN; Pancreatic cysts; Ulcerative colitis; IBS; Brachyspira;

    Sammanfattning : Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against infection and inflammation, but may also contribute to carcinogenesis and tumour progression. LÄS MER

  4. 3. Improved human papillomavirus DNA typing methods and biology of cervival cancer

    Författare :Biying Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical cancer; human papillomavirus; Pyrosequencing; chemokine receptors; adenoassociated virus; biomarkers; and cell cycle checkpoint.;

    Sammanfattning : Cervical cancer is the second most common cancer among women worldwide. Persistent HPV has been identified as a main risk factor in cervical cancer development. Oncoproteins E6 and E7 of highrisk HPV interact with cellular proteins, subverting cell cycle checkpoint, inducing carcinogenesis. LÄS MER

  5. 4. DNA adducts formed by ethene and butadiene : quantitative analysis in rats and humans

    Författare :Chunyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabelling; cancer; genotoxicity; ethene; ethylene oxide; 1; 3-butadiene; epoxybutanediol;

    Sammanfattning : The present study has focused on DNA adduct formation by two important industrial and environmental chemicals, ethene and butadiene, in rats and humans. Ethene and butadiene are among the 50 chemicals produced in greatest volume in the United States. LÄS MER

  7. 5. iLocks: a novel tool for RNA assays with improved specificity

    Författare :Tomasz Krzywkowski; Mats Nilsson; Gunnar von Heijne; Weng-Onn Lui; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA; miRNA; non-coding RNA; padlock probes; rolling circle amplification; invader; single cell; in situ; adenovirus; virology; diagnostics; Biochemistry; biokemi;

    Sammanfattning : The Central Dogma of molecular biology describes a framework for how genetic information is transferred in cells, placing RNA as a messenger between DNA and translated proteins. During the last years, interest in RNA research has grown tremendously due to the increasing understanding and recognition of the importance of RNA in regulation of gene expression, biochemical catalysis, and genome integrity surveillance. LÄS MER