Sökning: "homology-based modeling"

Hittade 2 avhandlingar innehållade orden homology-based modeling.

  1. 1. Mechanisms and mediators of apoptosis : with special reference to hematological disorders

    Författare :Bengt Fadeel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; Bcl-2; caspases; chemotherapy; chronic granulomatous disease; familial hemophagocytic lymphohistiocytosis; Fas; homology-based modeling; neutrophils; phosphatidylserine; reactive oxygen species;

    Sammanfattning : Life and death are inextricably entwined. Naturally occurring cell death or apoptosis is essential for the of homeostasis and serves to remove extraneous or dangerous cells in a swift and unobtrusive manner. work has demonstrated that such cell death is genetically regulated and transpires according to evolutionarily conserved pathways. LÄS MER

  3. 2. Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system

    Författare :Sara Nilsson; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atypical hemolytic uremic syndrome; deficiency; Complement inhibition; factor I; renal disease;

    Sammanfattning : Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. LÄS MER