Sökning: "homing receptors"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden homing receptors.

  1. 1. EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA

    Författare :Hanna Stenstad; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; Immunology; serology; homing; intestine; GALT; chemokine receptor; lymphocyte; serologi;

    Sammanfattning : The intestinal mucosa, including the intestinal epithelium and underlying lamina propria (LP), contains a large number of effector/memory T cells that are thought to play a central role in the generation and maintenance of mucosal immune responses and in maintaining mucosal integrity. The work in this thesis investigates the mechanisms regulating effector T cell recruitment to the small intestinal mucosa focusing on the role of chemokine receptors in this process. LÄS MER

  2. 2. Phenotype and function of CD25+ regulatory T cells in infants and adults

    Författare :Hanna Grindebacke; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Immunology; CD4 CD25 FOXP3 regulatory T cells; human; allergy; IL-10; Systemic immunotherapy; migration; homing receptors; maturation;

    Sammanfattning : Active suppression by CD4+CD25+FOXP3+ regulatory T cells (Treg) is essential for the maintenance of peripheral tolerance to both self antigens and environmental antigens. Absence of these cells in human newborns leads to autoimmune and inflammatory disorders as well as allergic disease. LÄS MER

  3. 3. T lymphocyte recruitment in Helicobacter pylori-associated diseases

    Författare :Karin Enarsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Helicobacter pylori; homing; T lymphocytes; gastric adenocarcinoma; regulatory T cells;

    Sammanfattning : Helicobacter pylori (Hp) infection is associated with pronounced infiltration of granulocytes and lymphocytes into the gastric mucosa, resulting in active chronic gastritis that may develop into duodenal ulcer disease or gastric adenocarcinoma (GC). Infiltrating T cells play a major role in the pathology of these diseases, but the signals involved in recruitment of T cells from blood to H. LÄS MER

  4. 4. Chemokine Receptor CCR9: Studies on the Generation and Localization of Gut Tropic Lymphocytes

    Författare :Marcus Svensson Frej; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine; transplantation; serologi; CCR9; CCL25; chemokines; lymphocyte homing; Immunology; serology; Immunologi;

    Sammanfattning : Lymphocytes are important mediators of adaptive immune responses. Naive T lymphocytes circulate in the blood and lymph between different secondary lymphoid organs in search for their specific antigen. LÄS MER

  5. 5. The ontogeny and function of intestinal dendritic cells

    Författare :Emma Persson; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenteric lymph nodes; Intestine; Dendritic cells; Gut-homing; Th17 cells; Oral tolerance; Immunity;

    Sammanfattning : The intestinal mucosa presents a huge surface area to the external environment and the intestinal immune system is continually exposed to a wide array of foreign antigens derived from resident intestinal microbiota as well as dietary constituents, including food proteins. In order to maintain intestinal homeostasis, the intestinal immune system relies on the ability to generate tolerogenic responses to innocuous antigen while maintaining the ability to develop effective immune responses to intesinal pathogens. LÄS MER