Sökning: "homeostatic plasticity"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden homeostatic plasticity.

  1. 1. Functional Relevance of Homeostatic Intrinsic Plasticity in Neurons and Networks

    Författare :Yann Sweeney; Jeanette Hällgren Kotaleski; Matthias Hennig; Thomas Nowotny; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer Science; Datalogi;

    Sammanfattning : Maintaining the intrinsic excitability of neurons is crucial for stable brain activity. This can be achieved by the homeostatic regulation of membrane ion channel conductances, although it is not well understood how these processes influence broader aspects of neuron and network function. LÄS MER

  3. 2. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia

    Författare :Tim Fieblinger; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Parkinson’s disease; L-DOPA-induced dyskinesia; ERK1 2; mGluR5; homeostatic plasticity; SPN; 2‑Photon microscopy;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. LÄS MER

  4. 3. Neurotransmission and functional synaptic plasticity in the rat medial preoptic nucleus

    Författare :Evgenya Malinina; Staffan Johansson; Eric Hanse; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medial preoptic nucleus; synaptic plasticity; GABA; glutamate; L-type Ca2 channel; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : Brain function implies complex information processing in neuronal circuits, critically dependent on the molecular machinery that enables signal transmission across synaptic contacts between neurons. The types of ion channels and receptors in the neuronal membranes vary with neuron types and brain regions and determine whether neuronal responses will be excitatory or inhibitory and often allow for functional synaptic plasticity which is thought to be the basis for much of the adaptability of the nervous system and for our ability to learn and store memories. LÄS MER

  5. 4. Neuronal assembly formation and non-random recurrent connectivity induced by homeostatic structural plasticity

    Författare :Julia Gallinaro; Pawel Herman; Alexander Kozlov; Stefan Rotter; Wulfram Gerstner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Plasticity is usually classified into two distinct categories: Hebbian or homeostatic. Hebbian is driven by correlation in the activity of neurons, while homeostatic relies on a negative feedback signal to control neuronal activity. LÄS MER

  7. 5. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control

    Författare :Johanna Hörberg; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcriptional control; Gene expression regulation; DNA supercoiling; DNA methylation; DNA-protein recognition; Basic-Leucine-Zipper transcription factors; Basic-Helix-Loop-Helix transcription factors; Sequence specific DNA plasticity; Transcription factor cooperativity; Cancer; Molecular modelling; Molecular dynamics;

    Sammanfattning : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. LÄS MER